Gallic acid-based indanone derivatives as anticancer agents.

Abstract

Gallic acid-based indanone derivatives have been synthesised. Some of the indanones showed very good anticancer activity in MTT assay. Compounds 10, 11, 12 and 14 possessed potent anticancer activity against various human cancer cell lines. The most potent indanone (10, IC(50)=2.2 microM), against MCF-7, that is, hormone-dependent breast cancer cell line, showed no toxicity to human erythrocytes even at higher concentrations (100 microg/ml, 258 microM). While, indanones 11, 12 and 14 showed toxicities to erythrocytes at higher concentrations.

• Authors: Hari Om Saxena, Uzma Faridi, Suchita Srivastava, J K Kumar, M P Darokar, Suaib Luqman, C S Chanotiya, Vinay Krishna, Arvind S Negi, S P S Khanuja
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 18 Issue 14 Pg. 3914-8 (Jul 15 2008) ISSN: 1464-3405 [Electronic] England
• PMID: 18586491 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Antioxidants
• Indans
• Tetrazolium Salts
• Thiazoles
• Gallic Acid
• thiazolyl blue

Topics

• Antineoplastic Agents (chemical synthesis, pharmacology)
• Antioxidants (pharmacology)
• Cell Line, Tumor
• Chemistry, Pharmaceutical (methods)
• Drug Design
• Drug Screening Assays, Antitumor
• Erythrocytes (drug effects)
• Gallic Acid (chemistry)
• Hemolysis
• Humans
• Indans (chemical synthesis, chemistry)
• Inhibitory Concentration 50
• Models, Chemical
• Osmosis
• Tetrazolium Salts (pharmacology)
• Thiazoles (pharmacology)