Momilactone B, an allelochemical of rice hulls, induces apoptosis on human lymphoma cells (Jurkat) in a micromolar concentration.

Abstract

Although momilactone B has been studied as an allelochemical of rice (Oryza sativa L.), to date we have no report showing the effect of momilactone B on mammalian cells. This study was undertaken to examine whether this allelochemical has anticancer activity on cancer cells. We show here that momilactone B at micromolar doses has antitumor efficacy by inducing apoptosis in several blood cancer cells including human leukemic T cells. In addition, our study elucidated that anticancer activity of momilactone B on human leukemic T cells resulted from the induction of apoptosis via caspase and mitochondria. From these results, momilactone B can be considered as a novel therapeutic strategy for human leukemic T cells from its direct apoptosis-inducing activity.

• Authors: Seung C Lee, Ill-Min Chung, Yeong J Jin, Yeon S Song, Su Y Seo, Bong S Park, Kwang H Cho, Ki S Yoo, Tae-Hyun Kim, Su-Bog Yee, Yoe-Sik Bae, Young H Yoo
• Journal: Nutrition and cancer (Nutr Cancer) Vol. 60 Issue 4 Pg. 542-51 ( 2008) ISSN: 1532-7914 [Electronic] United States
• PMID: 18584489 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Diterpenes
• Lactones
• momilactone B
• Caspase 3

Topics

• Antineoplastic Agents, Phytogenic (administration & dosage)
• Apoptosis (drug effects)
• Caspase 3 (physiology)
• Cell Count
• Cell Survival (drug effects)
• Diterpenes (administration & dosage)
• Dose-Response Relationship, Drug
• Humans
• Jurkat Cells
• Lactones (administration & dosage)
• Membrane Potential, Mitochondrial (drug effects)
• Oryza (chemistry)
• Seeds (chemistry)
• T-Lymphocytes (drug effects)