Abstract |
Although momilactone B has been studied as an allelochemical of rice (Oryza sativa L.), to date we have no report showing the effect of momilactone B on mammalian cells. This study was undertaken to examine whether this allelochemical has anticancer activity on cancer cells. We show here that momilactone B at micromolar doses has antitumor efficacy by inducing apoptosis in several blood cancer cells including human leukemic T cells. In addition, our study elucidated that anticancer activity of momilactone B on human leukemic T cells resulted from the induction of apoptosis via caspase and mitochondria. From these results, momilactone B can be considered as a novel therapeutic strategy for human leukemic T cells from its direct apoptosis-inducing activity.
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Authors | Seung C Lee, Ill-Min Chung, Yeong J Jin, Yeon S Song, Su Y Seo, Bong S Park, Kwang H Cho, Ki S Yoo, Tae-Hyun Kim, Su-Bog Yee, Yoe-Sik Bae, Young H Yoo |
Journal | Nutrition and cancer
(Nutr Cancer)
Vol. 60
Issue 4
Pg. 542-51
( 2008)
ISSN: 1532-7914 [Electronic] United States |
PMID | 18584489
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Diterpenes
- Lactones
- momilactone B
- Caspase 3
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Topics |
- Antineoplastic Agents, Phytogenic
(administration & dosage)
- Apoptosis
(drug effects)
- Caspase 3
(physiology)
- Cell Count
- Cell Survival
(drug effects)
- Diterpenes
(administration & dosage)
- Dose-Response Relationship, Drug
- Humans
- Jurkat Cells
- Lactones
(administration & dosage)
- Membrane Potential, Mitochondrial
(drug effects)
- Oryza
(chemistry)
- Seeds
(chemistry)
- T-Lymphocytes
(drug effects)
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