[Changes in kinetics of deaminated biogenic amines in spontaneous hypertension].

Abstract

Rate of serotonin and benzylamine deamination was increased in liver tissue of rats with spontaneous hypertension. The increase was due to elevation in Vmax value for monoamine oxidases of the A and B types as compared with the corresponding values of control animals. The Vmax value was increased in kidney of hypertensive animals for MAO of the B type (benzylamine as a substrate). At the same time, Km for MAO of the B type was increased in liver tissue, while Km for MAO of the A type was decreased in brain of hypertensive animals. Titration of the MAO active sites exhibited their increased concentration in the B type MAO in liver mitochondria of experimental animals. The data obtained suggest an important role of alterations in the MAO catalytic activity in pathogenesis of spontaneous hypertension.

• Authors: D I Ioffina, I E Smirnov, V Z Gorkin
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1991 Jan-Feb Vol. 37 Issue 1 Pg. 59-63 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Izmemeniia kinetiki dezaminirovaniia biogennykh aminov pri spontannoĭ gipertenzii.
• PMID: 1858344 (Publication Type: English Abstract, Journal Article)

Chemical References

• Amines
• Benzylamines
• Biogenic Amines
• Monoamine Oxidase Inhibitors
• Serotonin
• benzylamine
• Monoamine Oxidase

Topics

• Amines (chemistry)
• Animals
• Benzylamines (metabolism)
• Biogenic Amines (metabolism)
• Brain (metabolism)
• Hypertension (metabolism)
• Kinetics
• Liver (metabolism)
• Mitochondria (enzymology, metabolism)
• Monoamine Oxidase (metabolism)
• Monoamine Oxidase Inhibitors (pharmacology)
• Rats
• Rats, Inbred Strains
• Serotonin (metabolism)