Pharmacokinetics-pharmacodynamics of quinolones against Streptococcus pneumoniae in patients with community-acquired pneumonia.

Abstract

Exposure-response analyses were performed using data from 89 patients (10 clinical trials) with Streptococcus pneumoniae community-acquired pneumonia who received quinolones. Relationships between the free-drug AUC/MIC ratio and clinical and microbiologic response were identified. Such data may be useful to establish prior expectations for the no-treatment effect when conducting noninferiority clinical trials.

• Authors: Sujata M Bhavnani, Alan Forrest, Jeffrey P Hammel, George L Drusano, Christopher M Rubino, Paul G Ambrose
• Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 62 Issue 1 Pg. 99-101 (Sep 2008) ISSN: 0732-8893 [Print] United States
• PMID: 18583085 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Quinolones

Topics

• Anti-Bacterial Agents (pharmacokinetics, therapeutic use)
• Area Under Curve
• Community-Acquired Infections (drug therapy, epidemiology, microbiology)
• Humans
• Microbial Sensitivity Tests
• Pneumonia, Pneumococcal (drug therapy, epidemiology, microbiology)
• Quinolones (pharmacokinetics, therapeutic use)
• Streptococcus pneumoniae (drug effects)
• Treatment Outcome