The effects of Tordon 202c exposure on urethan-induced lung adenoma formation in female CD-1 mice.

Abstract

Female CD-1 mice were exposed to Tordon 202c, a herbicide containing 2,4-dichlorophenoxyacetic acid and picloram, in the drinking water for 15 w at concentrations ranging from 0 to 0.3% of the product formulation. After 3 w of the 15-w treatment period, the mice received 1.5 mg/g urethan ip. Pulmonary adenoma production was evaluated 12 w later. Tordon 202c exposure produced a dose-dependent increase in tumor number, but had no effect on tumor size. Urethan-induced sleeping times which reflected the rate of urethan metabolism or excretion were altered, but a specific dose-related effect which could be correlated with tumor production was not observed. This suggests that Tordon 202c exposure influences adenoma formation by immunological mechanisms rather than by causing indirect effects on urethan metabolism or excretion.

• Authors: S L Adams, S T Horvat, A E Irwin, R W Junkin, N M Koreman, B R Blakley
• Journal: Veterinary and human toxicology (Vet Hum Toxicol) Vol. 33 Issue 3 Pg. 209-11 (Jun 1991) ISSN: 0145-6296 [Print] United States
• PMID: 1858296 (Publication Type: Journal Article)

Chemical References

• Herbicides
• sangor
• 2,4-Dichlorophenoxyacetic Acid
• Urethane
• Picloram

Topics

• 2,4-Dichlorophenoxyacetic Acid (administration & dosage, toxicity)
• Adenoma (chemically induced)
• Animals
• Dose-Response Relationship, Drug
• Drinking
• Drug Synergism
• Female
• Herbicides (administration & dosage, toxicity)
• Lung Neoplasms (chemically induced)
• Mice
• Picloram (administration & dosage, toxicity)
• Urethane