HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Forskolin protects keratinocytes from UVB-induced apoptosis and increases DNA repair independent of its effects on melanogenesis.

Abstract
Melanin pigments provide efficient protection against ultraviolet B (UVB) radiation but DNA repair also plays a key role in eliminating UV-induced damage and preventing the development of skin cancers. In this study, we demonstrate that forskolin (FSK), an agent that increases intracellular levels of cAMP, protects keratinocytes from UVB-induced apoptosis independently from the amount of melanin in the skin. FSK enhances the removal of the two major types of UVB-induced DNA damage, cyclobutane pyrimidine dimers and 6,4-photoproducts, by facilitating DNA repair. These findings suggest new preventive approaches with topical formulations of FSK or other bioactive agents that could be applied to the skin before sun exposure to increase its ability to repair DNA damage.
AuthorsThierry Passeron, Takeshi Namiki, Hélène J Passeron, Elodie Le Pape, Vincent J Hearing
JournalThe Journal of investigative dermatology (J Invest Dermatol) Vol. 129 Issue 1 Pg. 162-6 (Jan 2009) ISSN: 1523-1747 [Electronic] United States
PMID18580960 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)
Chemical References
  • Culture Media
  • Colforsin
  • Cyclic AMP
Topics
  • Apoptosis
  • Cells, Cultured
  • Colforsin (metabolism, pharmacology)
  • Culture Media (pharmacology)
  • Cyclic AMP (metabolism)
  • DNA Damage
  • DNA Repair
  • Epidermis (pathology)
  • Humans
  • Keratinocytes (cytology, metabolism)
  • Melanocytes (cytology)
  • Models, Biological
  • Skin (pathology)
  • Skin Pigmentation
  • Ultraviolet Rays

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: