Involvement of hippocampal serotonin and neuropeptide Y in depression induced by chronic unpredicted mild stress.

Abstract

Accumulated evidence indicates a role of the hippocampal 5-hydroxy-tryptamine (5-HT) and neuropeptide Y (NPY) in the response to stress and modulation of depression, but it is unclear whether and how the hippocampal 5-HT and NPY systems make contributions to chronic unpredicted mild stress (CUMS)-induced depression. Here we observed that rats receiving a variety of chronic unpredictable mild stressors for 3 weeks showed a variety of depression-like behavioral changes, including a significant reduction in body weight, sucrose preference, and locomotion, rearing and grooming in open field test, and a significant increase in immobility time in forced swimming test. These CUMS-induced behavioral changes were suppressed or blocked by intra-hippocampal injection of 5-HT (31.25 microg/microl) or NPY (10 microg/microl). These data suggest a critical role of reduced hippocampal 5-HT and NPY neurotransmission in CUMS-induced depression.

• Authors: D D Luo, S C An, X Zhang
• Journal: Brain research bulletin (Brain Res Bull) Vol. 77 Issue 1 Pg. 8-12 (Sep 05 2008) ISSN: 1873-2747 [Electronic] United States
• PMID: 18579108 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Neuropeptide Y
• Serotonin

Topics

• Animals
• Behavior, Animal (drug effects, physiology)
• Body Weight (drug effects, physiology)
• Chronic Disease
• Depressive Disorder (etiology, prevention & control, psychology)
• Disease Models, Animal
• Exploratory Behavior (drug effects, physiology)
• Food Preferences (drug effects, psychology)
• Grooming (drug effects, physiology)
• Hippocampus (metabolism)
• Immobilization (physiology, psychology)
• Male
• Microinjections (methods)
• Motor Activity (drug effects, physiology)
• Neuropeptide Y (administration & dosage, metabolism, pharmacology)
• Rats
• Rats, Sprague-Dawley
• Serotonin (administration & dosage, metabolism, pharmacology)
• Stress, Psychological (complications)
• Swimming (psychology)