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Laminin-5 (gamma2 chain) is a marker of invading cancer cells in human gallbladder carcinoma: special emphasis on extension of carcinoma in situ along Rokitansky-Aschoff sinuses.

Abstract
Gallbladder carcinoma (GC) is a relatively uncommon malignancy and is often caused by diagnostic difficulties in distinguishing the extension of carcinoma in situ (CIS) from invasive carcinoma along Rokitansky-Aschoff sinuses (RAS). The laminin-5, a heterotrimer, is composed of alpha-3, beta-3 and gamma-2 chains. The gamma-2 chain is expressed in various invasive carcinoma cells. There are numerous reports that have described that laminin-5-gamma-2 is associated with tissue invasion in many organs. However, few studies are found in gallbladder carcinoma. To clarify the relationship between laminin-5-gamma-2 chain (LN-5) expression and the development of GCs, we performed an immunohistochemical study of 93 GCs. Cases were classified into three groups: CIS with/without the extension along RAS (Group A; n=17), carcinoma invading mucosa or muscular layer (Group B; n=5) and carcinoma invading beyond perimuscular connective tissue (Group C; n=71). The immunohistochemical intracytoplasmic expression was detected in the invasive fronts of the tumor. In the invasive components of Group B and C, LN-5 was expressed in 100 and 97% of cases, respectively, whereas in the CIS lesions of GCs, expression was not observed in Group A. LN-5 expression in the GCs tended to increase as tumors developed, which may be an indicator of the potential invasiveness of the tumor. Our results indicate that, in GCs, a strong intracytoplasmic expression of LN-5 was identified in the cancer cells whether in situ they extend along RAS or invading stroma.
AuthorsTakashi Eguchi, Takahiro Inoue, Kei Fujii, Hiroshi Yamaguchi, Ken-Ichi Nishiyama, Hirotoshi Yonemasu, Takashi Yao, Masao Tanaka, Masazumi Tsuneyoshi
JournalOncology reports (Oncol Rep) Vol. 20 Issue 1 Pg. 33-9 (Jul 2008) ISSN: 1021-335X [Print] Greece
PMID18575715 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers, Tumor
  • Cell Adhesion Molecules
  • kalinin
Topics
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor (analysis)
  • Carcinoma in Situ (chemistry, diagnosis, pathology)
  • Cell Adhesion Molecules (analysis)
  • Female
  • Gallbladder Neoplasms (chemistry, diagnosis, pathology)
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Invasiveness

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