HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

The neovasculature homing motif NGR: more than meets the eye.

Abstract
A growing body of evidence suggests that peptides containing the Asn-Gly-Arg (NGR) motif can selectively recognize tumor neovasculature and can be used, therefore, for ligand-directed targeted delivery of various drugs and particles to tumors or to other tissues with an angiogenesis component. The neovasculature binding properties of these peptides rely on the interaction with an endothelium-associated form of aminopeptidase N (CD13), an enzyme that has been implicated in angiogenesis and tumor growth. Recent studies have shown that NGR can rapidly convert to isoaspartate-glycine-arginine (isoDGR) by asparagine deamidation, generating alpha(v)beta(3) ligands capable of affecting endothelial cell functions and tumor growth. This review focuses on structural and functional properties of the NGR motif and its application in drug development for angiogenesis-dependent diseases. Furthermore, we discuss the time-dependent transition of NGR to isoDGR in natural proteins, such as fibronectins, and its potential role of as a "molecular timer" for generating new binding sites for integrins impli-cated in angiogenesis.
AuthorsAngelo Corti, Flavio Curnis, Wadih Arap, Renata Pasqualini
JournalBlood (Blood) Vol. 112 Issue 7 Pg. 2628-35 (Oct 1 2008) ISSN: 1528-0020 [Electronic] United States
PMID18574027 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Integrins
  • NGR peptide
  • Oligopeptides
Topics
  • Amino Acid Motifs
  • Animals
  • Cell Adhesion
  • Drug Delivery Systems
  • Humans
  • Integrins (metabolism)
  • Neovascularization, Pathologic (metabolism)
  • Oligopeptides (administration & dosage, chemistry, metabolism, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: