Abstract | OBJECTIVE: To analyse the contribution of socio-demographics, clinical profile and psychotropic treatment on remission in patients with schizophrenia. METHODS: Among 933 French outpatients recruited in the European observational Schizophrenia Outpatient Health Outcomes study (SOHO), 563 were followed-up for 3 years, had at most one missing visit, and were included in the analysis. Symptomatic remission was defined as a score of 3 (mild severity) or less on the Clinical Global Impression- Schizophrenia (CGI) overall, positive, negative and cognitive symptom scales, maintained for at least 6 months and without hospitalization. A logistic regression model was used to analyse the factors associated with time in remission. RESULTS: 60.6% of patients achieved remission during the 3-year follow-up. Patients never treated before inclusion in the study (OR=2.3) and those having paid employment (OR=1.4) were more likely to achieve remission. Higher baseline clinical severity was associated with a significantly lower likelihood of achieving remission: CGI overall (OR=0.67), CGI positive (OR=0.85) and CGI negative (OR=0.74). Compared with olanzapine, other atypicals (OR=0.71) and conventional antipsychotics (OR=0.69) were associated with a lower probability of achieving remission. CONCLUSIONS: Remission can be achieved in a high proportion of patients. Factors such as being previously untreated, having paid employment and taking olanzapine are predictors of remission.
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Authors | Isabelle Gasquet, Josep Maria Haro, Stéphanie Tcherny-Lessenot, Florence Chartier, Jean-Pierre Lépine |
Journal | European psychiatry : the journal of the Association of European Psychiatrists
(Eur Psychiatry)
Vol. 23
Issue 7
Pg. 491-6
(Oct 2008)
ISSN: 0924-9338 [Print] England |
PMID | 18573640
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Ambulatory Care
(methods, statistics & numerical data)
- Cohort Studies
- Female
- Follow-Up Studies
- France
- Humans
- Male
- Outcome Assessment, Health Care
(statistics & numerical data)
- Prevalence
- Remission Induction
- Schizophrenia
(classification, drug therapy)
- Severity of Illness Index
- Time Factors
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