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A case of *-fetoprotein-producing pulmonary carcinoma with restricted expression of hepatocyte nuclear factor-4* in hepatoid foci: a case report with studies of previous cases.

Abstract
We report a case of *-fetoprotein (AFP)-producing pulmonary carcinoma with studies for messenger RNA (mRNA) expression of hepatocyte nuclear factor (HNF)-4*, which is a transcription factor that is highly expressed in the process of liver development. The patient was a 64-year-old man with a pulmonary tumor in his left lower lobe. Serum AFP was 673 ng/mL. The microscopic analysis of the surgical specimen revealed a large cell neuroendocrine carcinoma with occasional hepatoid foci. The competitive reverse transcriptase polymerase chain reaction analysis revealed that HNF-4* mRNA was expressed on the order of 10(2)- to 10(3)-fold more abundantly than control pulmonary carcinomas and normal lung tissues. In addition, AFP and HNF-4* expression was restricted in hepatoid foci. Two previously reported cases of AFP-producing pulmonary carcinoma were also positive, whereas all 18 control pulmonary carcinomas were negative for HNF-4*. These findings suggest that aberrant expression of HNF-4* is implicated in the emergence or maintenance of hepatoid foci in AFP-producing pulmonary carcinomas.
AuthorsTakashi Kishimoto, Tomoyuki Yano, Kenzo Hiroshima, Yoshiaki Inayama, Kae Kawachi, Yukio Nakatani
JournalHuman pathology (Hum Pathol) Vol. 39 Issue 7 Pg. 1115-20 (Jul 2008) ISSN: 1532-8392 [Electronic] United States
PMID18570977 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Hepatocyte Nuclear Factor 4
  • RNA, Messenger
  • alpha-Fetoproteins
Topics
  • Biomarkers, Tumor (metabolism)
  • Carcinoma, Hepatocellular (diagnosis, metabolism)
  • Carcinoma, Neuroendocrine (metabolism, pathology, surgery)
  • Diagnosis, Differential
  • Gene Expression
  • Hepatocyte Nuclear Factor 4 (genetics, metabolism)
  • Humans
  • Immunoenzyme Techniques
  • Lung Neoplasms (metabolism, pathology, surgery)
  • Male
  • Middle Aged
  • RNA, Messenger (metabolism)
  • Reverse Transcriptase Polymerase Chain Reaction
  • alpha-Fetoproteins (metabolism)

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