Abstract |
We report a case of *- fetoprotein (AFP)-producing pulmonary carcinoma with studies for messenger RNA ( mRNA) expression of hepatocyte nuclear factor (HNF)-4*, which is a transcription factor that is highly expressed in the process of liver development. The patient was a 64-year-old man with a pulmonary tumor in his left lower lobe. Serum AFP was 673 ng/mL. The microscopic analysis of the surgical specimen revealed a large cell neuroendocrine carcinoma with occasional hepatoid foci. The competitive reverse transcriptase polymerase chain reaction analysis revealed that HNF-4* mRNA was expressed on the order of 10(2)- to 10(3)-fold more abundantly than control pulmonary carcinomas and normal lung tissues. In addition, AFP and HNF-4* expression was restricted in hepatoid foci. Two previously reported cases of AFP-producing pulmonary carcinoma were also positive, whereas all 18 control pulmonary carcinomas were negative for HNF-4*. These findings suggest that aberrant expression of HNF-4* is implicated in the emergence or maintenance of hepatoid foci in AFP-producing pulmonary carcinomas.
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Authors | Takashi Kishimoto, Tomoyuki Yano, Kenzo Hiroshima, Yoshiaki Inayama, Kae Kawachi, Yukio Nakatani |
Journal | Human pathology
(Hum Pathol)
Vol. 39
Issue 7
Pg. 1115-20
(Jul 2008)
ISSN: 1532-8392 [Electronic] United States |
PMID | 18570977
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Hepatocyte Nuclear Factor 4
- RNA, Messenger
- alpha-Fetoproteins
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Topics |
- Biomarkers, Tumor
(metabolism)
- Carcinoma, Hepatocellular
(diagnosis, metabolism)
- Carcinoma, Neuroendocrine
(metabolism, pathology, surgery)
- Diagnosis, Differential
- Gene Expression
- Hepatocyte Nuclear Factor 4
(genetics, metabolism)
- Humans
- Immunoenzyme Techniques
- Lung Neoplasms
(metabolism, pathology, surgery)
- Male
- Middle Aged
- RNA, Messenger
(metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
- alpha-Fetoproteins
(metabolism)
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