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Wen-pi-tang-Hab-Wu-ling-san attenuates kidney fibrosis induced by ischemia/reperfusion in mice.

Abstract
Renal fibrosis is highly implicated as a cause of chronic renal failure, for which suitable therapeutics have not yet been developed. Recently, it was reported that Wen-pi-tang-Hab-Wu-ling-san (WHW) extract attenuates epithelial cells undergoing mesenchymal transition in cultured Madin-Darby canine kidney cells. This study investigated whether WHW extract prevents renal fibrosis induced by ischemia/reperfusion (I/R) in mice. Ischemia/reperfusion resulted in kidney fibrosis at 14 days after the procedure. When WHW was administered orally to mice beginning from 2 days after the onset of ischemia until killing, the fibrosis was significantly reduced. WHW administration significantly prevented a post-ischemic decrease of copper-zinc superoxide dismutase (CuZnSOD) and manganese superoxide dismutase (MnSOD) activities, leading to decreased lipid peroxidation and hydrogen peroxide production. In addition, WHW administration attenuated the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase 1/2 (JNK1/2) and attenuated the activation of nuclear factor-kappa B (NF-kappaB) in the kidneys subjected to ischemia. In conclusion, WHW extract attenuated the renal fibrosis and the attenuation was associated with a reduction of oxidative stress and an inhibition of ERK1/2, JNK1/2, p38 and NF-kappaB activation. WHW extract may be an attractive agent to attenuate the progression of fibrosis.
AuthorsYoung Mi Seok, Jinu Kim, Mae Ja Park, Yong Chool Boo, Yong-Ki Park, Kwon Moo Park
JournalPhytotherapy research : PTR (Phytother Res) Vol. 22 Issue 8 Pg. 1057-63 (Aug 2008) ISSN: 1099-1573 [Electronic] England
PMID18570213 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Drugs, Chinese Herbal
  • NF-kappa B
  • Hydrogen Peroxide
  • Superoxide Dismutase
  • Mitogen-Activated Protein Kinase 3
  • Mitogen-Activated Protein Kinase 8
Topics
  • Animals
  • Disease Models, Animal
  • Drugs, Chinese Herbal (therapeutic use)
  • Fibrosis (metabolism, pathology, prevention & control)
  • Hydrogen Peroxide (metabolism)
  • Kidney (metabolism, pathology)
  • Kidney Failure, Chronic (drug therapy, metabolism, pathology)
  • Lipid Peroxidation (drug effects)
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mitogen-Activated Protein Kinase 3 (antagonists & inhibitors, metabolism)
  • Mitogen-Activated Protein Kinase 8 (antagonists & inhibitors, metabolism)
  • NF-kappa B (antagonists & inhibitors, metabolism)
  • Oxidative Stress (drug effects)
  • Phosphorylation
  • Reperfusion Injury (drug therapy, metabolism, pathology)
  • Superoxide Dismutase (metabolism)

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