Abstract |
To update the data on the expression of ' mesothelioma markers' by serous carcinomas of various sites we have studied cases from ovary (n=56), endometrium (n=37), fallopian tube (n=6), primary peritoneum (n=5) and cervix (n=3) using a panel of antibodies (WT1, P53, estrogen receptors, HER2/neu, D2-40, cytokeratin 5/6 and E-cadherin). Ovarian carcinomas demonstrated D2-40 and cytokeratin 5/6 immunoreactivity in 23.2 and 55.4% of cases, respectively. Endometrial carcinomas demonstrated D2-40 and cytokeratin 5/6 immunoreactivity in 43.2 and 37.8% of cases, respectively. D2-40 staining pattern was predominantly focal; however, strong reactivity was identified in 16.2% of endometrial and 10.7% of ovarian carcinomas. HER2/neu oncoprotein overexpression was demonstrated in 7 of 37 (18.9%) uterine serous carcinomas. In contrast, all the serous carcinomas of the other sites were HER2/neu negative. The proportion of positive cases was significantly different in ovarian vs endometrial carcinomas regarding WT1 (P=0.0458), estrogen receptors (P<0.001) reactivity and HER2/neu overexpression (P=0.0025). D2-40 and cytokeratin 5/6 are expressed in a considerable proportion of serous carcinomas and should be used cautiously in a ' mesothelioma panel' in situations where serous carcinoma is in the differential diagnosis. HER2/neu was exclusively overexpressed in serous carcinomas of endometrial origin.
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Authors | Sharon Nofech-Mozes, Mahmoud A Khalifa, Nadia Ismiil, Reda S Saad, Wedad M Hanna, Al Covens, Zeina Ghorab |
Journal | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
(Mod Pathol)
Vol. 21
Issue 9
Pg. 1147-55
(Sep 2008)
ISSN: 1530-0285 [Electronic] United States |
PMID | 18567994
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Murine-Derived
- Biomarkers, Tumor
- Keratin-5
- Keratin-6
- Receptors, Estrogen
- monoclonal antibody D2-40
- Receptor, ErbB-2
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Topics |
- Aged
- Antibodies, Monoclonal
(metabolism)
- Antibodies, Monoclonal, Murine-Derived
- Biomarkers, Tumor
(metabolism)
- Cystadenocarcinoma, Serous
(diagnosis, metabolism)
- Female
- Genital Neoplasms, Female
(diagnosis, metabolism)
- Humans
- Immunophenotyping
- Keratin-5
(metabolism)
- Keratin-6
(metabolism)
- Middle Aged
- Receptor, ErbB-2
(metabolism)
- Receptors, Estrogen
(metabolism)
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