Abstract | OBJECTIVE: In a randomized controlled split-face trial to evaluate efficacy and adverse effects from rejuvenation with long- pulsed dye laser (LPDL) versus intense pulsed light (IPL). MATERIALS AND METHODS: Twenty female volunteers with Fitzpatrick skin types I-III, classes I-II rhytids, and symmetrical split-face photodamage were included in the study. Subjects received a series of three treatments at 3-week intervals with half-face LPDL (V-beam Perfecta, 595 nm, Candela Laser Corporation) and half-face IPL (Ellipse Flex, Danish Dermatologic Development); the interventions being randomly assigned to left and right sides. Primary end-points were telangiectasias, irregular pigmentation and preferred treatment. Secondary end-points were skin texture, rhytids, pain, and adverse effects. Efficacy was evaluated by patient self-assessments and by blinded clinical on-site and photographic evaluations at 1, 3, and 6 months postoperatively. Adverse effects were evaluated by blinded clinical on-site evaluations. RESULTS:
Telangiectasia improved from LPDL and IPL treatments with superior vessel clearance from LPDL treatments (postoperative side-to-side evaluations, patient self-assessments, P<or=0.031, 3, 6 months). Irregular pigmentation and skin texture improved from both treatments with no significant side-to-side differences. No reduction was seen of rhytides on LPDL- or IPL-treated sides. Treatment-related pain scores were significantly higher after IPL (medians 7-8) than LPDL (4.75-5.5) treatments (P<0.001). Adverse effects included erythema, oedema, and transient hyperpigmentation. Patients preferred LPDL- to IPL treatments (P<or=0.031). CONCLUSION: This study was based on two specific laser and IPL equipments, which found LPDL rejuvenation advantageous to IPL rejuvenation due to superior vessel clearance and less pain.
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Authors | Gitte F Jørgensen, Lene Hedelund, Merete Haedersdal |
Journal | Lasers in surgery and medicine
(Lasers Surg Med)
Vol. 40
Issue 5
Pg. 293-9
(Jul 2008)
ISSN: 0196-8092 [Print] United States |
PMID | 18563775
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Double-Blind Method
- Face
- Female
- Humans
- Lasers, Dye
(adverse effects, therapeutic use)
- Middle Aged
- Pain, Postoperative
(etiology)
- Patient Satisfaction
- Phototherapy
(adverse effects)
- Pigmentation Disorders
(etiology)
- Skin Aging
- Treatment Outcome
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