Topical application of royal jelly has a healing effect for 5-fluorouracil-induced experimental oral mucositis in hamsters.

Abstract

The aim of this study was to evaluate the effects of bee products such as honey, royal jelly and propolis on 5-fluorouracil-induced experimental oral mucositis in hamsters. Oral mucositis was induced in hamsters through a combination of 5-fluorouracil and mild abrasions that were made on the cheek pouch. Honey, royal jelly and propolis were thereafter topically administered to the oral mucosa, and then the healing process was examined by measuring the size of the mucositis. Honey (1%, 10% and 100%) and propolis (0.3%, 1% and 3%) ointments did not reduce the size of the mucositis in comparison to the vaseline-treated control group. However, the royal jelly (3%, 10% and 30%) ointments significantly improved the recovery from 5-fluorouracil-induced damage in a dose-dependent manner. These results suggest the possibility that the topical application of royal jelly has a healing effect on severe oral mucositis induced by chemotherapy.

• Authors: K Suemaru, R Cui, B Li, S Watanabe, K Okihara, K Hashimoto, H Yamada, H Araki
• Journal: Methods and findings in experimental and clinical pharmacology (Methods Find Exp Clin Pharmacol) Vol. 30 Issue 2 Pg. 103-6 (Mar 2008) ISSN: 0379-0355 [Print] Spain
• PMID: 18560624 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2008 Prous Science, S.A.U. or its licensors. All rights reserved.

Chemical References

• Fatty Acids
• Growth Substances
• Propolis
• royal jelly
• Fluorouracil

Topics

• Administration, Topical
• Animals
• Cricetinae
• Fatty Acids (administration & dosage)
• Fluorouracil (toxicity)
• Growth Substances (physiology)
• Honey
• Mesocricetus
• Propolis
• Stomatitis (chemically induced, drug therapy)
• Wound Healing