The antimalarial trioxaquine DU1301 alkylates heme in malaria-infected mice.

Abstract

The in vivo alkylation of heme by the antimalarial trioxaquine DU1301 afforded covalent heme-drug adducts that were detected in the spleens of Plasmodium sp.-infected mice. This result indicates that the alkylation capacities of trioxaquines in mammals infected with Plasmodium strains are similar to that of artemisinin, a natural antimalarial trioxane-containing drug.

• Authors: Fatima Bousejra-El Garah, Catherine Claparols, Françoise Benoit-Vical, Bernard Meunier, Anne Robert
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 52 Issue 8 Pg. 2966-9 (Aug 2008) ISSN: 1098-6596 [Electronic] United States
• PMID: 18559651 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antimalarials
• DU1301
• Sesquiterpenes
• Heme

Topics

• Animals
• Antimalarials (chemistry, pharmacology)
• Chromatography, Liquid
• Heme (chemistry, metabolism)
• Malaria (drug therapy, metabolism)
• Mass Spectrometry
• Mice
• Molecular Structure
• Sesquiterpenes (chemistry, pharmacology)