Abstract | PURPOSE: EXPERIMENTAL DESIGN: The rats implanted with 9L gliosarcoma were dosed orally with hydroxyurea and L-arginine. BTB permeability, defined by the unidirectional transport constant, Ki, for [14C] sucrose was measured. The expression of neural and endothelial NO synthase (NOS) in tumors and normal brain tissue was examined. Further, the levels of NO, L- citrulline, and cGMP in the tumor and normal brain tissue were measured. RESULTS: CONCLUSIONS:
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Authors | Dali Yin, Xiao Wang, Bindu M Konda, John M Ong, Jinwei Hu, Manuel R Sacapano, Minhee K Ko, Andres J Espinoza, Dwain K Irvin, Yan Shu, Keith L Black |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 14
Issue 12
Pg. 4002-9
(Jun 15 2008)
ISSN: 1078-0432 [Print] United States |
PMID | 18559623
(Publication Type: Journal Article)
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Chemical References |
- Nitric Oxide Donors
- Citrulline
- Nitric Oxide
- Arginine
- Nitric Oxide Synthase
- Cyclic GMP
- Hydroxyurea
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Topics |
- Administration, Oral
- Animals
- Arginine
(administration & dosage, pharmacology)
- Blood-Brain Barrier
(drug effects, physiology)
- Brain Neoplasms
(metabolism, pathology, physiopathology)
- Capillary Permeability
(drug effects, physiology)
- Citrulline
(metabolism)
- Cyclic GMP
(metabolism)
- Drug Delivery Systems
- Drug Evaluation, Preclinical
- Drug Synergism
- Female
- Glioma
(metabolism, pathology, physiopathology)
- Hydroxyurea
(administration & dosage, pharmacology)
- Nitric Oxide
(metabolism)
- Nitric Oxide Donors
(pharmacology)
- Nitric Oxide Synthase
(metabolism)
- Rats
- Rats, Inbred F344
- Tumor Cells, Cultured
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