Decline of T cell-related immune functions in cancer patients and an attempt to restore them through infusion of activated autologous T cells.
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| Abstract |
We developed a scoring system that can combine several immunological parameters and express the immune status of individuals as a simple numeral. T cell immune score was obtained by using 5T cell-related parameters: number of T cells, ratio of CD4(+)T cells to CD8(+)T cells, number of naïve T cells, ratio of naïve T cells to memory T cells, and T cell proliferative index (TCPI). TCPI was calculated by using number of T cells and their proliferative activity. We assessed T cell immune score in 103 patients with colorectal cancer and 51 healthy age-matched controls. The results were as follows: (1) T cell-immune score of patients in stages I-IV before surgery was significantly decreased as compared with controls. (2) The number of regulatory T cells in patients in stages I-IV gradually increased with disease progression. (3) T cell immune score was strongly suppressed after surgery, but were recovered to the initial level within a month. (4) Furthermore, restoration of immunological function was attempted in cancer patients by infusion of activated autologous T cells. The effectiveness was confirmed by an increase of TCPI in many cancer patients.
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| Authors | Katsuiku Hirokawa, Masanori Utsuyama, Toshiaki Ishikawa, Yuko Kikuchi, Masanobu Kitagawa, Yuzo Fujii, Hideo Nariuchi, Hiroyuki Uetake, Kenichi Sugihara |
| Journal | Mechanisms of ageing and development (Mech Ageing Dev) 2009 Jan-Feb Vol. 130 Issue 1-2 Pg. 86-91 ISSN: 0047-6374 [Print] Ireland |
| PMID | 18555517 (Publication Type: Controlled Clinical Trial, Journal Article) |
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