Isopropanolic Cimicifuga racemosa is favorable on bone markers but neutral on an osteoblastic cell line.

Abstract

Postmenopausal women treated with an isopropanolic extract of Cimicifuga racemosa underwent a decrease in the urinary concentration of N-telopeptides, a marker of bone resorption, and an increase in alkaline phosphatase, a marker of bone formation, at the third month of therapy. Serum from treated women did not modify the activity of alkaline phosphatase or the expression of three genes, runt-related transcription factor-2 (Runx-2), alkaline phosphatase, and osteocalcin, when added to the MC3T3-E1 osteoblastic cell line.

• Authors: Miguel Angel García-Pérez, Begoña Pineda, Carlos Hermenegildo, Juan J Tarín, Antonio Cano
• Journal: Fertility and sterility (Fertil Steril) Vol. 91 Issue 4 Suppl Pg. 1347-50 (Apr 2009) ISSN: 1556-5653 [Electronic] United States
• PMID: 18555220 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Collagen Type I
• Core Binding Factor Alpha 1 Subunit
• Peptides
• Plant Extracts
• RUNX2 protein, human
• collagen type I trimeric cross-linked peptide
• Osteocalcin
• Alkaline Phosphatase
• 2-Propanol

Topics

• 2-Propanol
• Alkaline Phosphatase (metabolism)
• Animals
• Biomarkers (metabolism)
• Bone Resorption (physiopathology)
• Bone and Bones (drug effects, metabolism)
• Cell Line
• Cimicifuga
• Collagen Type I (urine)
• Core Binding Factor Alpha 1 Subunit (metabolism)
• Female
• Humans
• Mice
• Osteoblasts (drug effects, metabolism)
• Osteocalcin (metabolism)
• Osteogenesis (drug effects, physiology)
• Peptides (urine)
• Phytotherapy
• Plant Extracts (pharmacology, therapeutic use)
• Postmenopause (drug effects, physiology)
• Prospective Studies