Abstract | BACKGROUND: CASE: A 64-year-old woman with stage IIIC fallopian tube cancer developed acute mental status changes and radiologic findings consistent with RPLS in conjunction with hypertension after one cycle of intravenous paclitaxel, followed by intraperitoneal (IP) cisplatin. Symptoms resolved over the course of 4 days with no obvious residual effects. CONCLUSION: The use of an intravenous paclitaxel and intraperitoneal cisplatin regimen can be associated with RPLS. Hypertension should be controlled in patients prior to receiving this chemotherapy regimen due to potential toxicity.
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Authors | N Onujiogu, E Lengyel, S D Yamada |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 111
Issue 3
Pg. 537-9
(Dec 2008)
ISSN: 1095-6859 [Electronic] United States |
PMID | 18554701
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Cisplatin
(administration & dosage, adverse effects)
- Fallopian Tube Neoplasms
(drug therapy)
- Female
- Humans
- Infusions, Intravenous
- Infusions, Parenteral
- Middle Aged
- Paclitaxel
(administration & dosage, adverse effects)
- Posterior Leukoencephalopathy Syndrome
(chemically induced)
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