[Arthroplasty for the treatment of joint degeneration caused by ochronosis in two cases].

Abstract

Ochronosis is a rare metabolic disease caused by the deficiency of the homogentisic acid oxidase enzyme. With increasing age, accumulation of pigment deposits of homogentisic acid in the joint cartilage results in ochronotic osteoarthritis. We presented two female patients, with ages 55 and 60 years, who underwent staged bilateral uncemented total hip and bilateral cemented total knee arthroplasty, respectively, for osteoarthritis caused by ochronosis. Both patients had no significant complaints at final follow-up examinations made 12 months and 10 months after the second operation in the hip and knee, respectively. Plain radiographs did not show any abnormality in the components of the prostheses. Histopathologic examination of surgical specimens showed brown-black pigment deposits in the connective tissue and cartilage tissue.

• Authors: Mehmet Kefeli, Yilmaz Tomak, Bilge Can, Sancar Bariş
• Journal: Acta orthopaedica et traumatologica turcica (Acta Orthop Traumatol Turc) 2008 Mar-Apr Vol. 42 Issue 2 Pg. 139-44 ISSN: 1017-995X [Print] Turkey
• Vernacular Title: Iki olguda okronozise bağli eklem dejenerasyonunda artroplasti uygulamalari.
• PMID: 18552537 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Arthroplasty, Replacement, Hip (methods)
• Arthroplasty, Replacement, Knee (methods)
• Female
• Humans
• Joint Diseases (etiology, surgery)
• Middle Aged
• Ochronosis (complications, surgery)
• Treatment Outcome