Abstract | UNLABELLED: The imaging of neuroendocrine tumors has become one of the most significant areas in nuclear oncology. In an attempt to provide high-quality imaging and possible sensitivity at a reduced cost, time, and radiation dose, several (99m)Tc agents have been proposed. The aim of this initial study was to compare the tumor uptake and biodistribution of 2 new 6-hydrazinopyridine-3-carboxylic acid (HYNIC)-derivatized Tyr(3)-octreotide analogs, (99m)Tc-[HYNIC, Tyr(3)]octreotide ((99m)Tc-TOC) and (99m)Tc-[HYNIC,Tyr(3),Thr(8)] octreotide ((99m)Tc-TATE), in patients with somatostatin receptor-expressing tumors. METHODS: Each of 12 patients with proven gastrointestinal pancreatic neuroendocrine tumors received a mean activity of 520 MBq of (99m)Tc-TOC and (99m)Tc-TATE. Scintigraphy with both tracers was performed 3-4 h after their injection using standard whole-body and SPECT imaging. The images were reviewed subjectively by 2 readers, who reported tumor uptake lesion by lesion. RESULTS: Both radiotracers demonstrated concordance between the results in 7 patients (58%). In total, 110 sites of disease were identified with (99m)Tc-TOC, compared with 115 with (99m)Tc-TATE. There was 1 case in which (99m)Tc-TOC identified sites of disease not seen on (99m)Tc-TATE imaging but 4 cases in which some sites of disease were seen with (99m)Tc-TATE and not (99m)Tc-TOC. CONCLUSION: In this initial study, both tracers seem to show similar sites of tumor, with (99m)Tc-TATE having a slight edge in the total number of lesions seen, especially in lymph node metastases.
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Authors | Jaroslaw B Cwikla, Renata Mikolajczak, Dariusz Pawlak, John R Buscombe, Anna Nasierowska-Guttmejer, Andrzej Bator, Helmut R Maecke, Jerzy Walecki |
Journal | Journal of nuclear medicine : official publication, Society of Nuclear Medicine
(J Nucl Med)
Vol. 49
Issue 7
Pg. 1060-5
(Jul 2008)
ISSN: 0161-5505 [Print] United States |
PMID | 18552141
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Organotechnetium Compounds
- Radiopharmaceuticals
- Receptors, Somatostatin
- technetium Tc 99m hydrazinonicotinyl-Tyr(3)-Thr(8)-octreotide
- technetium Tc 99m hydrazinonicotinyl-Tyr(3)-octreotide
- Octreotide
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Topics |
- Adult
- Aged
- Female
- Humans
- Intestinal Neoplasms
(diagnostic imaging, metabolism, pathology)
- Liver Neoplasms
(diagnostic imaging, metabolism, secondary)
- Lymphatic Metastasis
- Male
- Middle Aged
- Neuroendocrine Tumors
(diagnostic imaging, metabolism, secondary)
- Octreotide
(analogs & derivatives)
- Organotechnetium Compounds
- Pancreatic Neoplasms
(diagnostic imaging, metabolism, pathology)
- Prospective Studies
- Radiopharmaceuticals
- Receptors, Somatostatin
(biosynthesis)
- Tomography, Emission-Computed, Single-Photon
- Whole Body Imaging
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