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Initial direct comparison of 99mTc-TOC and 99mTc-TATE in identifying sites of disease in patients with proven GEP NETs.

AbstractUNLABELLED:
The imaging of neuroendocrine tumors has become one of the most significant areas in nuclear oncology. In an attempt to provide high-quality imaging and possible sensitivity at a reduced cost, time, and radiation dose, several (99m)Tc agents have been proposed. The aim of this initial study was to compare the tumor uptake and biodistribution of 2 new 6-hydrazinopyridine-3-carboxylic acid (HYNIC)-derivatized Tyr(3)-octreotide analogs, (99m)Tc-[HYNIC,Tyr(3)]octreotide ((99m)Tc-TOC) and (99m)Tc-[HYNIC,Tyr(3),Thr(8)]octreotide ((99m)Tc-TATE), in patients with somatostatin receptor-expressing tumors.
METHODS:
Each of 12 patients with proven gastrointestinal pancreatic neuroendocrine tumors received a mean activity of 520 MBq of (99m)Tc-TOC and (99m)Tc-TATE. Scintigraphy with both tracers was performed 3-4 h after their injection using standard whole-body and SPECT imaging. The images were reviewed subjectively by 2 readers, who reported tumor uptake lesion by lesion.
RESULTS:
Both radiotracers demonstrated concordance between the results in 7 patients (58%). In total, 110 sites of disease were identified with (99m)Tc-TOC, compared with 115 with (99m)Tc-TATE. There was 1 case in which (99m)Tc-TOC identified sites of disease not seen on (99m)Tc-TATE imaging but 4 cases in which some sites of disease were seen with (99m)Tc-TATE and not (99m)Tc-TOC.
CONCLUSION:
In this initial study, both tracers seem to show similar sites of tumor, with (99m)Tc-TATE having a slight edge in the total number of lesions seen, especially in lymph node metastases.
AuthorsJaroslaw B Cwikla, Renata Mikolajczak, Dariusz Pawlak, John R Buscombe, Anna Nasierowska-Guttmejer, Andrzej Bator, Helmut R Maecke, Jerzy Walecki
JournalJournal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 49 Issue 7 Pg. 1060-5 (Jul 2008) ISSN: 0161-5505 [Print] United States
PMID18552141 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • Receptors, Somatostatin
  • technetium Tc 99m hydrazinonicotinyl-Tyr(3)-Thr(8)-octreotide
  • technetium Tc 99m hydrazinonicotinyl-Tyr(3)-octreotide
  • Octreotide
Topics
  • Adult
  • Aged
  • Female
  • Humans
  • Intestinal Neoplasms (diagnostic imaging, metabolism, pathology)
  • Liver Neoplasms (diagnostic imaging, metabolism, secondary)
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neuroendocrine Tumors (diagnostic imaging, metabolism, secondary)
  • Octreotide (analogs & derivatives)
  • Organotechnetium Compounds
  • Pancreatic Neoplasms (diagnostic imaging, metabolism, pathology)
  • Prospective Studies
  • Radiopharmaceuticals
  • Receptors, Somatostatin (biosynthesis)
  • Tomography, Emission-Computed, Single-Photon
  • Whole Body Imaging

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