[Case of Carney complex complicated with pituitary adenoma and Rathke cleft cyst].

Abstract

Carney complex is a rare autosomal-dominant, familial tumor syndrome first described in the mid 80's. This syndrome is multiple neoplasia syndrome featuring cardiac, endocrine, cutaneous, and neural tumor, in addition to a variety of pigmented lesions of the skin and mucosa. We report the case of a 12-year-old female patient with Carney complex who manifested a high value of serum growth hormone (s-GH), cutaneous angiomyxomas and labial pigmented lesions. Magnetic resonance imaging (MRI) revealed a cystic pituitary tumor. We carried out removal of the pituitary tumor via the transsphenoidal approach. In addition to the pituitary adenoma, pathological examination revealed the presence of a Rathke cleft cyst. So far, approximately 500 cases of this disorder have been described, but there have been no cases similar to our case described here. Therefore, the present case seems to be the first case of Carney Complex complicated with pituitary adenoma and Rathke cleft cyst.

• Authors: Yuuta Kamoshima, Yutaka Sawamura, Yoshinobu K Iwasaki, Kenji Fujieda, Hiroyuki Takahashi
• Journal: No shinkei geka. Neurological surgery (No Shinkei Geka) Vol. 36 Issue 6 Pg. 535-9 (Jun 2008) ISSN: 0301-2603 [Print] Japan
• PMID: 18548895 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Biomarkers, Tumor

Topics

• Adenoma (complications, diagnosis, surgery)
• Angiomyoma (complications, diagnosis)
• Biomarkers, Tumor (analysis)
• Central Nervous System Cysts (complications, diagnosis)
• Child
• Female
• Humans
• Hyperpigmentation (complications, diagnosis)
• Magnetic Resonance Imaging
• Multiple Endocrine Neoplasia (complications, diagnosis)
• Neoplasms, Multiple Primary
• Pituitary Neoplasms (complications, diagnosis, surgery)
• Skin Neoplasms (complications, diagnosis)
• Syndrome