Anticancer photodynamic and non-photodynamic effects of pterin derivatives on a pancreatic cancer cell line.

Abstract

To evaluate the feasibility of two kinds of pterin derivatives, 2-(N,N-dimethylaminomethyleneamino)-6-formyl-3-pivaloylpteridin-4-one (DFP) and 2-(N,N-dimethylaminomethyleneamino)-3-pivaloylpteridin-4-one (DP), as anticancer drugs, their photodynamic and non-photodynamic effects on pancreatic cancer cell line Panc-1 cells were examined. For photodynamic effects, cell death 48 h after UV-A irradiation was more prominent in cells preloaded with DP than DFP. When cells were simply incubated for 96 h without irradiation, DFP induced cell death, while DP suppressed cell proliferation. Furthermore, DP was much more soluble in water than DFP. These findings collectively indicated that DP is more feasible as an anticancer drug than DFP.

• Authors: Takashi Miyoshi, Toshiyuki Arai, Mitsuru Nonogawa, Keisuke Makino, Hiroko Mori, Kouhei Yamashita, Masataka Sasada
• Journal: Journal of pharmacological sciences (J Pharmacol Sci) Vol. 107 Issue 2 Pg. 221-5 (Jun 2008) ISSN: 1347-8613 [Print] Japan
• PMID: 18544897 (Publication Type: Journal Article)

Chemical References

• 2-(N,N-dimethylaminomethyleneamino)-3-pivaloylpteridin-4-one
• 2-(N,N-dimethylaminomethyleneamino)-6-formyl-3-pivaloylpteridin-4-one
• Antineoplastic Agents
• Photosensitizing Agents
• Pteridines
• Pterins
• Reactive Oxygen Species

Topics

• Antineoplastic Agents (pharmacology)
• Cell Line, Tumor
• Humans
• Photochemotherapy
• Photosensitizing Agents (pharmacology)
• Pteridines (pharmacology)
• Pterins (pharmacology)
• Reactive Oxygen Species (metabolism)