[Repairing the defect of benign bone tumor with the coralline hydroxyapatite].

Abstract

OBJECTIVE:

To observe the clinical effect of repairing bone defectin post-operation benign tumor with coralline hydroxyapatite(CHAP).

METHODS:

The natural coralline was treated into coralline hydroxyapatite by "hydrothermal exchanging" at specific condition. The CHAP was implanted into the lesion after bone tumor curettage to 25 patients. The sizes of bone defect ranged from 0.8 cm x 0.5 cm x 0.5 cm to 10 cm x 3.5 cm x 2 cm.

RESULTS:

All patients had no abnormal local or systemic reactions. X-ray showed that there was osteogenesis at the cortical bone 1 month post-operation. The density of CHAP gradually reduced from 3 months. The clinical healing time was 4 months. The CHAP was nearly completely absorbed 18 months post-operation.

CONCLUSION:

The CHAP has favourable histocompatibility and osteroconduction in vivo. There is corresponding synchronization between bone formation with CHAP biodegradation. The CHAP is an excellent bone defect repairing material.

• Authors: Kun Fu, Zhi-bin Meng, Jun Li, Hong-chao Li
• Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (Zhong Nan Da Xue Xue Bao Yi Xue Ban) Vol. 33 Issue 5 Pg. 421-4 (May 2008) ISSN: 1672-7347 [Print] China
• PMID: 18544846 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Bone Substitutes
• Hydroxyapatites
• coralline hydroxyapatite

Topics

• Adolescent
• Adult
• Aged
• Bone Cysts (surgery)
• Bone Neoplasms (surgery)
• Bone Regeneration
• Bone Substitutes
• Ceramics
• Child
• Female
• Femur (surgery)
• Giant Cell Tumor of Bone (surgery)
• Humans
• Hydroxyapatites
• Male
• Middle Aged
• Prostheses and Implants