[The indication of steroid pulse therapy and apheresis therapy for multiple sclerosis].

Abstract

We discuss steroid pulse therapy and apheresis therapy indicated for the treatment of multiple sclerosis (MS). In the basic treatment course for MS, steroid pulse therapy is a first-line treatment for relapsing-remitting multiple sclerosis (RR-MS) in the course of the exacerbation, and apheresis therapy is performed in refractory cases. Treatment strategies for chronic progressive MS are not to be established. Steroid pulse therapy has been established as a treatment for MS in the active phase through randomized controlled trials (RCT). Apheresis therapy includes plasmapheresis and cytapheresis, and plasmapheresis includes plasma exchange (PE) and immunoadsorption plasmapheresis (IAPP). PE and IAPP are performed for MS treatment. PE has been established as a useful treatment for active phase MS. The efficacy of IAPP has been frequently reported, but no reports have been based on RCT. We also summarize the indications, methods, and adverse reactions of steroid pulse therapy and apheresis therapy.

• Authors: Satoru Ohji, Kyoichi Nomura
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 66 Issue 6 Pg. 1127-32 (Jun 2008) ISSN: 0047-1852 [Print] Japan
• PMID: 18540358 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Steroids

Topics

• Blood Component Removal
• Humans
• Multiple Sclerosis (therapy)
• Pulse Therapy, Drug
• Randomized Controlled Trials as Topic
• Steroids (administration & dosage)