Abstract |
Hb Regina was identified in a 58-year-old German male and 2 of his 3 children. All affected subjects presented moderate erythrocytosis and the whole blood exhibited increased oxygen affinity (P50:17.5 mm Hg). This hemoglobinopathy was undetectable with the conventional electrophoretic methods. It was, however, separated and quantified by cation-exchange and reverse-phase high-performance liquid chromatography. Hb Regina accounted for 30-35% of the total Hb. No significant clinical symptoms were found to be related to this hemoglobinopathy. This is the first known instance in Germany, and so far the second case reported.
|
Authors | E Bissé, H Wieland, H Ritschel |
Journal | Acta haematologica
(Acta Haematol)
Vol. 85
Issue 4
Pg. 212-6
( 1991)
ISSN: 0001-5792 [Print] Switzerland |
PMID | 1853685
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Diphosphoglyceric Acids
- Hemoglobins, Abnormal
- 2,3-Diphosphoglycerate
- hemoglobin Regina
- Leucine
- Valine
- Oxygen
|
Topics |
- 2,3-Diphosphoglycerate
- Chromatography, High Pressure Liquid
- Diphosphoglyceric Acids
(blood)
- Germany
- Hemoglobins, Abnormal
(analysis)
- Humans
- Leucine
- Male
- Middle Aged
- Oxygen
(blood)
- Polycythemia
(blood, genetics)
- Valine
|