Abstract | BACKGROUND AND PURPOSE: Bovine glycomacropeptide (BGMP) is an inexpensive, non-toxic milk peptide with anti-inflammatory effects in rat experimental colitis but its mechanism of action is unclear. It is also unknown whether BGMP can ameliorate inflammation in proximal regions of the intestine. Our aim was therefore two-fold: first, to determine the anti-inflammatory activity of BGMP in the ileum; second, to characterise its mechanism of action. EXPERIMENTAL APPROACH: We used a model of ileitis induced by trinitrobenzenesulphonic acid in rats. Rats were treated orally with BGMP and its efficacy compared with that of oral 5-aminosalicylic acid or vehicle, starting 2 days before ileitis induction. KEY RESULTS: CONCLUSIONS AND IMPLICATIONS: These results demonstrate that BGMP has anti-inflammatory activity in the ileum with similar efficacy to 5-aminosalicylic acid. The mechanism of action may involve Th17 and regulatory T cells and perhaps macrophages but probably not Th1 lymphocytes. Patients with Crohn's ileitis may benefit from treatment with BGMP.
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Authors | P Requena, A Daddaoua, E Martínez-Plata, M González, A Zarzuelo, M D Suárez, F Sánchez de Medina, O Martínez-Augustin |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 154
Issue 4
Pg. 825-32
(Jun 2008)
ISSN: 0007-1188 [Print] England |
PMID | 18536735
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Glycopeptides
- Interleukin-17
- Mesalamine
- Trinitrobenzenesulfonic Acid
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Topics |
- Administration, Oral
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Cattle
- Disease Models, Animal
- Down-Regulation
(drug effects)
- Female
- Glycopeptides
(pharmacology)
- Ileitis
(drug therapy, physiopathology)
- Interleukin-17
(metabolism)
- Macrophages
(drug effects, metabolism)
- Mesalamine
(pharmacology)
- Rats
- Rats, Wistar
- T-Lymphocytes, Helper-Inducer
(drug effects, metabolism)
- T-Lymphocytes, Regulatory
(drug effects, metabolism)
- Trinitrobenzenesulfonic Acid
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