[Effects of beta-asarone on expression of c-fos in kindling epilepsy rat brain].

Abstract

OBJECTIVE:

To study the effects of beta-asarone on expression of immediately early gene c-fos in kindling epilepsy rat brain.

METHOD:

The rats were randomly divided in to beta-asarone groups (200, 100, 50 mg x kg(-1) x d(-1)), difetoin control group (36 mg x kg(-1)) and model group. The remedy was administered orally. The effects were observed in kindling epilepsy model induced by penicillin, then the expression of c-fos were determined by western blot (hippocampus) and immunohistochemical techniques (cortex).

RESULT:

Beta-asarone could significantly increase the expression of c-fos in kindling epilepsy rat brain, and show its quantity-effect relation. The expression of c-fos in hippocampus was (1139.45 +/- 155.56), (1109.56 +/- 134.03), (1103.73 +/- 235.82) CNT x mm2 in beta-asarone groups, 920.54 +/- 203.20 in model control group, and 1106.26 +/- 186.24 in difetoin group, respectively. The number of c-fos positive cell was 87.1 +/- 2.2, 76.3 +/- 1.3 and 59.9 +/- 1.3 in beta-asarone groups, 39.3 +/- 2.6 in model control group, and 95.2 +/- 1.1 in difetoin group, respectively.

CONCLUSION:

Beta-asarone can obviously increase the expression of c-fos in epilepsy rat brain. It is one of important response to epilepsy.

• Authors: Yong-Qi Fang, Ruo-Ming Fang, Geng-Li Fang, Yong Jiang, Si-Ying Fu
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 33 Issue 5 Pg. 534-6 (Mar 2008) ISSN: 1001-5302 [Print] China
• PMID: 18536377 (Publication Type: Journal Article)

Chemical References

• Allylbenzene Derivatives
• Anisoles
• Proto-Oncogene Proteins c-fos
• asarone

Topics

• Allylbenzene Derivatives
• Animals
• Anisoles (pharmacology)
• Blotting, Western
• Brain (drug effects, metabolism)
• Epilepsy (drug therapy, metabolism)
• Female
• Gene Expression (drug effects)
• Immunohistochemistry
• Male
• Proto-Oncogene Proteins c-fos (metabolism)
• Random Allocation
• Rats
• Rats, Sprague-Dawley