Abstract |
Microvascular dysfunction in the cochlea has been considered the major cause of sudden hearing loss (SHL). For some time, prostaglandin E(1) ( PGE(1)), an effective vasodilator, has been used to treat patients with SHL, however the benefits of this therapy remain unclear. The present study assessed the efficacy of PGE(1) on SHL via a quantitative meta-analysis of 13 randomized controlled studies. The pooled odds ratio was 1.95 (95% confidence interval: 1.53, 2.50) and the test for overall effect (Z-value) was 5.31 (P < 0.00001), suggesting that PGE(1) is an effective and promising strategy for the treatment of SHL.
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Authors | Xian-Lu Zhuo, Yan Wang, Wen-Lei Zhuo, Xue-Yuan Zhang |
Journal | The Journal of international medical research
(J Int Med Res)
2008 May-Jun
Vol. 36
Issue 3
Pg. 467-70
ISSN: 0300-0605 [Print] England |
PMID | 18534127
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Chemical References |
- Vasodilator Agents
- Alprostadil
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Topics |
- Alprostadil
(therapeutic use)
- Bias
- Databases, Bibliographic
- Evidence-Based Medicine
- Hearing Loss, Sudden
(drug therapy)
- Humans
- Vasodilator Agents
(therapeutic use)
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