Abstract |
The pharmacokinetics of alprazolam was studied in 10 geriatric patients (5 males, 5 females) with neurotic depression during a 6-week period. After 0.5 mg of alprazolam on Day 1 the mean elimination half-life was 11.1 hr and Cmax 12.3 ng/ml. The pharmacokinetic evaluation on Day 1 (t 1/2, tmax) did not differ significantly from the evaluation on Day 42. The mean daily dosage on Day 42 was 1.6 mg alprazolam. The concentrations of the metabolites alpha- OH alprazolam and 4-OH alprazolam were less than 10% of that of alprazolam. All the patients improved clinically. The most common side effect was drowsiness, more often during the first week than the last week.
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Authors | O Dehlin, H Kullingsjö, A Lidén, B Agrell, G Moser, I Olsen |
Journal | Pharmacology & toxicology
(Pharmacol Toxicol)
Vol. 68
Issue 2
Pg. 121-4
(Feb 1991)
ISSN: 0901-9928 [Print] Denmark |
PMID | 1852717
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Alprazolam
(adverse effects, pharmacokinetics, therapeutic use)
- Depressive Disorder
(drug therapy, metabolism)
- Female
- Humans
- Male
- Middle Aged
- Psychiatric Status Rating Scales
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