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Sucutiniranes A and B, new cassane-type diterpenes from Bowdichia nitida.

Abstract
Two new cassane-type diterpenes, sucutiniranes A (1) and B (2), have been isolated from the seeds of Bowdichia nitida together with 6alpha-acetoxyvouacapane (3) and 6alpha,7beta-diacetoxyvouacapane (4), and the structures of 1 and 2 were elucidated by using 2D NMR data and chemical correlations. Sucutinirane A (1) and 3 showed a moderate cytotoxicity against human colon carcinoma COLO201 cells, and 6alpha,7beta-diacetoxyvouacapane (4) showed in vitro antiplasmodial activity against parasite Plasmodium falciparum 3D7.
AuthorsYosuke Matsuno, Jun Deguchi, Yusuke Hirasawa, Kunio Ohyama, Hiroo Toyoda, Chieko Hirobe, Wiwied Ekasari, Aty Widyawaruyanti, Noor Cholies Zaini, Hiroshi Morita
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 18 Issue 13 Pg. 3774-7 (Jul 1 2008) ISSN: 1464-3405 [Electronic] England
PMID18524584 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antimalarials
  • Diterpenes
  • Plant Extracts
  • sucutinirane A
  • sucutinirane B
Topics
  • Animals
  • Antimalarials (chemistry, pharmacology)
  • Carcinoma (drug therapy)
  • Cell Line, Tumor
  • Chemistry, Pharmaceutical (methods)
  • Colonic Neoplasms (drug therapy)
  • Diterpenes (chemistry, pharmacology)
  • Drug Design
  • Humans
  • Magnetic Resonance Spectroscopy
  • Models, Chemical
  • Plant Extracts (pharmacology)
  • Plants (metabolism)
  • Plasmodium falciparum (metabolism)
  • Seeds (metabolism)

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