Sucutiniranes A and B, new cassane-type diterpenes from Bowdichia nitida.

Abstract

Two new cassane-type diterpenes, sucutiniranes A (1) and B (2), have been isolated from the seeds of Bowdichia nitida together with 6alpha-acetoxyvouacapane (3) and 6alpha,7beta-diacetoxyvouacapane (4), and the structures of 1 and 2 were elucidated by using 2D NMR data and chemical correlations. Sucutinirane A (1) and 3 showed a moderate cytotoxicity against human colon carcinoma COLO201 cells, and 6alpha,7beta-diacetoxyvouacapane (4) showed in vitro antiplasmodial activity against parasite Plasmodium falciparum 3D7.

• Authors: Yosuke Matsuno, Jun Deguchi, Yusuke Hirasawa, Kunio Ohyama, Hiroo Toyoda, Chieko Hirobe, Wiwied Ekasari, Aty Widyawaruyanti, Noor Cholies Zaini, Hiroshi Morita
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 18 Issue 13 Pg. 3774-7 (Jul 01 2008) ISSN: 1464-3405 [Electronic] England
• PMID: 18524584 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antimalarials
• Diterpenes
• Plant Extracts
• sucutinirane A
• sucutinirane B

Topics

• Animals
• Antimalarials (chemistry, pharmacology)
• Carcinoma (drug therapy)
• Cell Line, Tumor
• Chemistry, Pharmaceutical (methods)
• Colonic Neoplasms (drug therapy)
• Diterpenes (chemistry, pharmacology)
• Drug Design
• Humans
• Magnetic Resonance Spectroscopy
• Models, Chemical
• Plant Extracts (pharmacology)
• Plants (metabolism)
• Plasmodium falciparum (metabolism)
• Seeds (metabolism)