Anti-cancer potential of gold complexes.

Abstract

A full range of gold compounds is currently being investigated for their potential as anti-tumor agents. Gold(I) compounds related to the anti-arthritic drug continue to attract attention, especially those carrying biologically active molecules with anti-tumor activity in their own right. Tetrahedrally coordinated gold(I) compounds, that possibly target mitochondria, are under development with a particular focus upon moderating their hydrophilicity. A resurgence of interest in square-planar gold(III) compounds has occurred in the last decade. A wide variety of species: mono- and di-nuclear, neutral and charged, coordination and organometallic, etc. are being developed. Supporting many investigations are studies of mechanistic aspects of gold compounds but a clear understanding of the mechanism of action of these compounds has yet to be delineated.

• Authors: E R T Tiekink
• Journal: Inflammopharmacology (Inflammopharmacology) Vol. 16 Issue 3 Pg. 138-42 (Jun 2008) ISSN: 0925-4692 [Print] Switzerland
• PMID: 18521545 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Organogold Compounds
• Auranofin

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Auranofin (analogs & derivatives)
• Humans
• Organogold Compounds (pharmacology)