Abstract |
A full range of gold compounds is currently being investigated for their potential as anti- tumor agents. Gold(I) compounds related to the anti-arthritic drug continue to attract attention, especially those carrying biologically active molecules with anti- tumor activity in their own right. Tetrahedrally coordinated gold(I) compounds, that possibly target mitochondria, are under development with a particular focus upon moderating their hydrophilicity. A resurgence of interest in square-planar gold(III) compounds has occurred in the last decade. A wide variety of species: mono- and di-nuclear, neutral and charged, coordination and organometallic, etc. are being developed. Supporting many investigations are studies of mechanistic aspects of gold compounds but a clear understanding of the mechanism of action of these compounds has yet to be delineated.
|
Authors | E R T Tiekink |
Journal | Inflammopharmacology
(Inflammopharmacology)
Vol. 16
Issue 3
Pg. 138-42
(Jun 2008)
ISSN: 0925-4692 [Print] Switzerland |
PMID | 18521545
(Publication Type: Journal Article, Review)
|
Chemical References |
- Antineoplastic Agents
- Organogold Compounds
- Auranofin
|
Topics |
- Animals
- Antineoplastic Agents
(pharmacology)
- Auranofin
(analogs & derivatives)
- Humans
- Organogold Compounds
(pharmacology)
|