HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effects of endolymphatic sac drainage with steroids for intractable Meniere's disease: a long-term follow-up and randomized controlled study.

AbstractOBJECTIVE:
Meniere's disease is a common inner ear disease with an incidence of 15 to 50 per 100,000 population. Since Meniere's disease is thought to be triggered by an immune insult to the inner ear, we examined intraendolymphatic sac application of steroids as a new therapeutic strategy for intractable Meniere's disease.
STUDY DESIGN:
Prospective randomized controlled study.
METHODS:
Between 1996 and 2005, we enrolled and assigned 197 intractable Meniere's patients to three groups in a randomized controlled trial: Group I (G-I)- patients who underwent endolymphatic sac drainage and steroid-instillation; Group II (G-II)-those who underwent endolymphatic sac drainage without steroid-instillation; and Group III (G-III)-those who declined endolymphatic sac drainage. Definitive spells and hearing in all three groups were determined for 2 to 7 years after treatment.
RESULTS:
According to the 1995 American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) criteria, 2-year results demonstrated that vertigo was completely controlled in 88.0% of patients in G-I (n = 100), 85.1% of patients in G-II (n = 47), and 8.0% in G-III (n = 50). Statistically, G-I = G-II>G-III. Hearing was improved in 49.0% of patients in G-I, 31.9% in G-II, and 6.0% in G-III (G-I>G-II>G-III). Results after 7 years showed that vertigo was completely controlled in 78.8% of patients in G-I, 79.2% in G-II, and 25.0% in G-III (G-I = G-II>G-III). Hearing improved in 36.5% of patients in G-I, 8.3% in G-II, and 0.0% in G-III (G-I>G-II = G-III).
CONCLUSIONS:
From non-surgical observation in G-III for at least 7 years after treatment, steroids instilled into endolymphatic sac in G-I patients significantly improved hearing in intractable Meniere's patients, more so than endolymphatic sac drainage without steroids in G-II patients.
AuthorsTadashi Kitahara, Takeshi Kubo, Shin-ichi Okumura, Masaaki Kitahara
JournalThe Laryngoscope (Laryngoscope) Vol. 118 Issue 5 Pg. 854-61 (May 2008) ISSN: 0023-852X [Print] United States
PMID18520184 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • Antidepressive Agents
  • Diuretics
  • Histamine H1 Antagonists
  • Piperidines
  • Dexamethasone
  • Dimenhydrinate
  • diphenidol
  • Diazepam
Topics
  • Anti-Inflammatory Agents (pharmacology, therapeutic use)
  • Antidepressive Agents (pharmacology, therapeutic use)
  • Dexamethasone (pharmacology, therapeutic use)
  • Diazepam (pharmacology, therapeutic use)
  • Dimenhydrinate (pharmacology, therapeutic use)
  • Diuretics (pharmacology, therapeutic use)
  • Endolymphatic Sac (drug effects)
  • Female
  • Follow-Up Studies
  • Histamine H1 Antagonists (pharmacology, therapeutic use)
  • Humans
  • Male
  • Meniere Disease (drug therapy)
  • Middle Aged
  • Piperidines (pharmacology, therapeutic use)
  • Prospective Studies

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: