Abstract | OBJECTIVE: STUDY DESIGN: Prospective randomized controlled study. METHODS: Between 1996 and 2005, we enrolled and assigned 197 intractable Meniere's patients to three groups in a randomized controlled trial: Group I (G-I)- patients who underwent endolymphatic sac drainage and steroid-instillation; Group II (G-II)-those who underwent endolymphatic sac drainage without steroid-instillation; and Group III (G-III)-those who declined endolymphatic sac drainage. Definitive spells and hearing in all three groups were determined for 2 to 7 years after treatment. RESULTS: According to the 1995 American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) criteria, 2-year results demonstrated that vertigo was completely controlled in 88.0% of patients in G-I (n = 100), 85.1% of patients in G-II (n = 47), and 8.0% in G-III (n = 50). Statistically, G-I = G-II>G-III. Hearing was improved in 49.0% of patients in G-I, 31.9% in G-II, and 6.0% in G-III (G-I>G-II>G-III). Results after 7 years showed that vertigo was completely controlled in 78.8% of patients in G-I, 79.2% in G-II, and 25.0% in G-III (G-I = G-II>G-III). Hearing improved in 36.5% of patients in G-I, 8.3% in G-II, and 0.0% in G-III (G-I>G-II = G-III). CONCLUSIONS: From non-surgical observation in G-III for at least 7 years after treatment, steroids instilled into endolymphatic sac in G-I patients significantly improved hearing in intractable Meniere's patients, more so than endolymphatic sac drainage without steroids in G-II patients.
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Authors | Tadashi Kitahara, Takeshi Kubo, Shin-ichi Okumura, Masaaki Kitahara |
Journal | The Laryngoscope
(Laryngoscope)
Vol. 118
Issue 5
Pg. 854-61
(May 2008)
ISSN: 0023-852X [Print] United States |
PMID | 18520184
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Antidepressive Agents
- Diuretics
- Histamine H1 Antagonists
- Piperidines
- Dexamethasone
- Dimenhydrinate
- diphenidol
- Diazepam
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Topics |
- Anti-Inflammatory Agents
(pharmacology, therapeutic use)
- Antidepressive Agents
(pharmacology, therapeutic use)
- Dexamethasone
(pharmacology, therapeutic use)
- Diazepam
(pharmacology, therapeutic use)
- Dimenhydrinate
(pharmacology, therapeutic use)
- Diuretics
(pharmacology, therapeutic use)
- Endolymphatic Sac
(drug effects)
- Female
- Follow-Up Studies
- Histamine H1 Antagonists
(pharmacology, therapeutic use)
- Humans
- Male
- Meniere Disease
(drug therapy)
- Middle Aged
- Piperidines
(pharmacology, therapeutic use)
- Prospective Studies
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