A total of 1290 patients were enrolled in a randomized multicentre double blind study in order to investigate the use of two doses of a new
low molecular weight heparin,
Logiparin, in the prevention of
deep vein thrombosis (DVT) in general surgery. Patients who were included had no
contraindication to
heparin therapy and had at least one of the recognized risk factors for DVT. Patients were randomized to receive
unfractionated heparin (UH) 5000 units b.d.,
Logiparin 2500 units daily or
Logiparin 3500 units daily. Each treatment was given subcutaneously 2 h before surgery and continued for 7-10 days. Daily 125I-labelled
fibrinogen uptake tests (FUTs) were performed from day 2 to day 7 to detect DVT, and phleboangiography was used to confirm the diagnosis. The
wound was examined on a daily basis to check for haematoma formation, and all patients were followed up for 1 month after operation. All three treatment arms were well matched for age, sex, weight, diagnosis and type of operation performed. The three major inclusion criteria in the trial were
malignancy, age over 60 years and a history of
varicose veins. Positive FUTs (UH = 4.2 per cent,
Logiparin 2500 units daily = 7.9 per cent,
Logiparin 3500 units daily = 3.7 per cent) and positive angiograms (UH = 3.0 per cent,
Logiparin 2500 units daily = 5.6 per cent,
Logiparin 3500 units daily = 2.3 per cent) were significantly more common in the
Logiparin 2500 units daily group than in the UH and
Logiparin 3500 units daily groups. The rates of major complications (severe haemorrhage, death,
pulmonary embolism, reintervention) were similar in the three groups.