Use of topical dorzolamide for patients with X-linked juvenile retinoschisis: case report.

Abstract

X-linked juvenile retinoschisis (XLRS) is a recessively inherited vitreoretinal degeneration characterized by macular pathology and splitting of the neuroretinal layers that is associated with alterations in the XLRS1 gene. There have been no therapeutic interventions known to be effective for patients with X-linked juvenile retinoschisis, but some studies are trying to determine the importance of dorzolamide for the treatment of foveal lesions in this disease. The authors, using optical coherence tomography, describe findings in a patient with X-linked juvenile retinoschisis, before and after a topical use of dorzolamide. Besides the improvement in his visual acuity, further studies are required to elucidate the real prevalence of nonresponse to dorzolamide and the frequency with which there may be a recurrence of foveal cystic changes during continued treatment.

• Authors: André Luís Carvalho de Moura Bastos, Bruno de Paula Freitas, Oscar Villas Boas, Alexandre Campelo Ramiro
• Journal: Arquivos brasileiros de oftalmologia (Arq Bras Oftalmol) 2008 Mar-Apr Vol. 71 Issue 2 Pg. 286-90 ISSN: 0004-2749 [Print] Brazil
• PMID: 18516436 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antihypertensive Agents
• Sulfonamides
• Thiophenes
• dorzolamide

Topics

• Administration, Topical
• Antihypertensive Agents (administration & dosage)
• Child
• Humans
• Male
• Radiography
• Retinoschisis (diagnostic imaging, drug therapy)
• Sulfonamides (administration & dosage)
• Thiophenes (administration & dosage)
• Time Factors