Abstract | BACKGROUND: METHODS: RESULTS: Both groups showed similar reductions of the serum PTH level and similar increases in serum calcium. In both groups, there were no significant changes in the serum phosphate level. Long-term daily oral calcitriol therapy failed to prevent the increase of both maximum PT volume and total volume, as assessed by ultrasonography; however, intravenous calcitriol therapy successfully suppressed this progression. In the daily, oral group, both the bone-specific alkaline phosphatase (BAP) and the N-telopeptide cross-linked of type I collagen (NTX) significantly decreased, which was probably due to the PTH suppression. However, these bone metabolism markers remained stable in the intravenous group. The total dosage of calcitriol during the study was comparable in both groups. CONCLUSIONS:
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Authors | Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya, Hideki Hirakata, Mitsuo Iida |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 23
Issue 11
Pg. 3662-9
(Nov 2008)
ISSN: 1460-2385 [Electronic] England |
PMID | 18515308
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Collagen Type I
- Parathyroid Hormone
- Peptides
- collagen type I trimeric cross-linked peptide
- Vitamin D
- Phosphorus
- Calcitriol
- Calcium
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Topics |
- Administration, Oral
- Aged
- Bone and Bones
(metabolism)
- Calcitriol
(administration & dosage, pharmacology, therapeutic use)
- Calcium
(blood)
- Collagen Type I
(metabolism)
- Dose-Response Relationship, Drug
- Female
- Humans
- Hyperparathyroidism, Secondary
(etiology, pathology, prevention & control)
- Hyperplasia
(prevention & control)
- Injections, Intravenous
- Longitudinal Studies
- Male
- Middle Aged
- Parathyroid Glands
(diagnostic imaging, drug effects, pathology)
- Parathyroid Hormone
(blood)
- Peptides
(metabolism)
- Phosphorus
(blood)
- Renal Dialysis
- Renal Insufficiency
(complications, therapy)
- Ultrasonography
- Vitamin D
(administration & dosage, pharmacology, therapeutic use)
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