N-phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats.

Abstract

The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator in vivo to be used in iron overload diseases. After intraperitoneal application of Phth-Gly-HA to male rats (1 mg kg(-1) body mass) once a day for seven days, iron serum level decreased by 21%, whereas the iron value dropped by 32% in female rats (1.5 mg kg(-1) body mass). The results indicate that the tested substance has the ability to bind serum iron by complexation. Besides transferrin iron release, mobilization of ferritin iron is also possible.

• Authors: Julija Matijević-Sosa, Ita Samarzija, Lorena Honović, Blazenka Jurisić
• Journal: Acta pharmaceutica (Zagreb, Croatia) (Acta Pharm) Vol. 58 Issue 2 Pg. 231-6 (Jun 2008) ISSN: 1330-0075 [Print] Poland
• PMID: 18515233 (Publication Type: Journal Article)

Chemical References

• Hydroxamic Acids
• Iron Chelating Agents
• Transferrin
• N-phthalylglycine
• Ferritins
• Iron
• Glycine

Topics

• Animals
• Drug Administration Schedule
• Female
• Ferritins (blood)
• Glycine (administration & dosage, analogs & derivatives, pharmacology)
• Hydroxamic Acids (administration & dosage, pharmacology)
• Injections, Intraperitoneal
• Iron (blood)
• Iron Chelating Agents (administration & dosage, pharmacology)
• Iron Overload (drug therapy, metabolism)
• Male
• Rats
• Rats, Wistar
• Transferrin (metabolism)