HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Pathogenicity and antigenicity of avian nephritis isolates.

Abstract
The G-4260, IR-N, M-6, and M-8 strains of avian nephritis virus (ANV) were inoculated orally into 1-day-old specific-pathogen-free chicks of the line PDL-1 for pathological and serological study. Five of 15 chicks inoculated with the G-4260 strain died with visceral urate depositions. One of 15 chicks each inoculated with the M-6 and M-8 strains died with nephrosis and visceral urate deposition, respectively. No chicks inoculated with the IR-N strain died. Mean body weights of ANV-inoculated chicks, except for the IR-N-inoculated chicks, at 14 days postinoculation (PI) were significantly lower than those of control chicks (P less than 0.01). However, interstitial nephritis was observed in all ANV-inoculated birds that were histopathologically examined at 14 days PI. In the serological study, the G-4260 and IR-N strains were classified as the same serotype, and the M-6 and M-8 strains were classified as a different serotype from the G-4260 and IR-N strains. These results indicate that there at least two serotypes of ANV and its strains differ in pathogenicity.
AuthorsJ Shirai, K Nakamura, K Shinohara, H Kawamura
JournalAvian diseases (Avian Dis) 1991 Jan-Mar Vol. 35 Issue 1 Pg. 49-54 ISSN: 0005-2086 [Print] United States
PMID1851420 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antigens, Viral
Topics
  • Animals
  • Antigens, Viral (analysis)
  • Body Weight
  • Chickens
  • Cross Reactions
  • Fluorescent Antibody Technique
  • Kidney (microbiology, pathology)
  • Neutralization Tests
  • Picornaviridae (immunology, pathogenicity)
  • Picornaviridae Infections (microbiology, veterinary)
  • Poultry Diseases (microbiology)
  • Specific Pathogen-Free Organisms

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: