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Phase II trial of amonafide in patients with stage III and IV non-small-cell lung cancer.

Abstract
Amonafide (benzisoquinolinedione, nafidimide, NSC 308847) is an anticancer agent that functions as a DNA intercalator. Sixteen patients with stage III or IV non-small-cell lung cancer who had not previously received chemotherapy were given amonafide at an initial dose of 300 mg/m2 i.v. daily for 5 days every 21 days. No major objective responses were observed among the 14 patients adequately treated (95% confidence limits 0-20%). Local reactions at the injection site or phlebitis were seen in 14 of the 16 patients. Leukopenia (44%), nausea or vomiting (38%), and thrombocytopenia and rash (each 25%) were also noted. With the low response rate and the toxicity observed, amonafide at this dosage and schedule has limited use in the treatment of non-small-cell lung cancer.
AuthorsM Z Berger, M G Kris, R J Gralla, L D Marks, L M Potanovich, J J Dimaggio, R T Heelan
JournalAmerican journal of clinical oncology (Am J Clin Oncol) Vol. 14 Issue 2 Pg. 124-6 (Apr 1991) ISSN: 0277-3732 [Print] United States
PMID1851387 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antineoplastic Agents
  • Imides
  • Intercalating Agents
  • Isoquinolines
  • Naphthalimides
  • Organophosphonates
  • amonafide
  • Adenine
Topics
  • Adenine
  • Adenocarcinoma (drug therapy)
  • Aged
  • Antineoplastic Agents (adverse effects, therapeutic use)
  • Carcinoma, Non-Small-Cell Lung (drug therapy)
  • Drug Evaluation
  • Drug Tolerance
  • Female
  • Humans
  • Imides
  • Intercalating Agents (adverse effects, therapeutic use)
  • Isoquinolines (adverse effects, therapeutic use)
  • Lung Neoplasms (drug therapy)
  • Male
  • Middle Aged
  • Naphthalimides
  • Neoplasm Staging
  • Organophosphonates
  • Remission Induction

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