Abstract | AIM: The aim of this study was to investigate the preventive actions of bezafibrate against non- alcoholic steatohepatitis (NASH), the activation of hepatic stellate cells (HSC), and fibrogenesis by using a model of NASH and an in vitro model. METHODS: Male KK-A(y)/TaJcl (KK-A(y)) mice were fed a methionine and choline-deficient (MCD) diet or a MCD diet containing bezafibrate or pioglitazone for 7 weeks, after which biochemical parameters, pathological changes, and hepatic mRNA levels were assessed. An in vitro HSC model was designed by using a previously described RI-T cell line stimulated by transforming growth factor-beta1 (TGF-beta1). RESULTS: CONCLUSION:
Bezafibrate improved hepatic steatosis and potently prevented inflammation, oxidative stress, HSC activation, and fibrogenesis in the liver. Moreover, this study was the first to demonstrate that bezafibrate directly inhibits hepatic fibrogenic response induced by TGF-beta1 in vitro. Hence bezafibrate may be a new therapeutic strategy against NASH and hepatic fibrosis.
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Authors | Shigeru Nakano, Tatsuya Nagasawa, Tomoyuki Ijiro, Yoichi Inada, Toru Tamura, Kazuyasu Maruyama, Junji Kuroda, Yoshinobu Yamazaki, Hiroshi Kusama, Nobuo Shibata |
Journal | Hepatology research : the official journal of the Japan Society of Hepatology
(Hepatol Res)
Vol. 38
Issue 10
Pg. 1026-39
(Oct 2008)
ISSN: 1386-6346 [Print] Netherlands |
PMID | 18513333
(Publication Type: Journal Article)
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