Antiplatelet cilostazol is beneficial in diabetic and/or hypertensive ischemic stroke patients. Subgroup analysis of the cilostazol stroke prevention study.

Abstract

BACKGROUND AND PURPOSE:

Although antiplatelets are known to be effective for secondary prevention of cerebral infarction, the number needed to treat is rather large and the effects in stroke patients with complications such as hypertension or diabetes are inadequately defined. This study was conducted to examine the effect of such complications on recurrence of cerebral infarction, and to assess the effect of cilostazol, an antiplatelet agent, in these high-risk subjects.

METHODS:

A post hoc subgroup analysis of the already reported Cilostazol Stroke Prevention Study, which was a placebo-controlled double-blind trial, has been carried out to clarify the influence of various complications on recurrence in the placebo group and the effects of cilostazol in 1,095 patients with noncardioembolic ischemic cerebrovascular disease. Treatment continued for an average of 1.8 +/- 1.3 years (maximum 4.8 years).

RESULTS:

The recurrence rate of the diabetic stroke patients was significantly higher compared with the nondiabetics in the placebo group (9.4 vs. 4.7%/year, p = 0.01). Furthermore, our study showed that the relative risk reduction (RRR) for recurrence of infarction was 41.7% with cilostazol. This treatment provided a significant benefit in patients with lacunar infarction (RRR 43.4%, p = 0.04), with diabetes (RRR 64.4%, p = 0.008), or with hypertension (RRR 58.0%, p = 0.003).

CONCLUSIONS:

Diabetic patients are particularly at risk for recurrence of cerebral infarction. Cilostazol is useful for the prevention of the recurrence of vascular events in patients with lacunar infarction, and is probably effective in high-risk patients with diabetes and/or hypertension.

• Authors: Yukito Shinohara, Fumio Gotoh, Hideo Tohgi, Shunsaku Hirai, Akiro Terashi, Yasuo Fukuuchi, Eiichi Otomo, Eiichi Itoh, Tamotsu Matsuda, Tohru Sawada, Takenori Yamaguchi, Katsuya Nishimaru, Yasuo Ohashi
• Journal: Cerebrovascular diseases (Basel, Switzerland) (Cerebrovasc Dis) Vol. 26 Issue 1 Pg. 63-70 ( 2008) ISSN: 1421-9786 [Electronic] Switzerland
• PMID: 18511873 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
• Copyright: (c) 2008 S. Karger AG, Basel

Chemical References

• Platelet Aggregation Inhibitors
• Tetrazoles
• Cilostazol

Topics

• Aged
• Brain Ischemia (complications, prevention & control)
• Cerebral Infarction (etiology, prevention & control)
• Cilostazol
• Diabetes Complications (drug therapy)
• Double-Blind Method
• Female
• Humans
• Hypertension (complications, drug therapy)
• Japan
• Male
• Middle Aged
• Platelet Aggregation Inhibitors (therapeutic use)
• Risk Assessment
• Risk Factors
• Secondary Prevention
• Tetrazoles (therapeutic use)
• Time Factors
• Treatment Outcome