The effect of travoprost on daytime intraocular pressure in normal tension glaucoma: a randomised controlled trial.

Abstract

BACKGROUND/AIMS:

To determine the medium-term effect of travoprost on the daytime intraocular pressure (IOP) of patients with normal tension glaucoma (NTG) METHODS: Newly diagnosed NTG patients underwent baseline, daytime, hourly IOP phasing. Patients were randomised to either treatment or no treatment (control). Treatment comprised once daily topical travoprost 0.004%. After 6 months, the participants underwent their second IOP phasing.

RESULTS:

Data from 88 participants were analysed-54 were randomised to treatment and 34 to the control group. The mean duration of treatment was 6 months. The average, maximum and minimum diurnal IOPs for treated patients were statistically significantly lower than for control patients at follow-up (p<0.001). When compared with baseline IOP, the travoprost treated group demonstrated a decrease of 16.1%, 13.5% and 16.7% in the average IOP, maximum IOP, and minimum IOP respectively. Of those treated, about one-third achieved a decrease in average IOP of at least 20%; only about one-tenth achieved a reduction of at least 30%.

CONCLUSION:

Travoprost monotherapy had a sustained hypotensive effect in NTG and achieved a reasonable or good response (>20% reduction in average IOP) in 32.9% of treated eyes. However, in the majority of eyes with NTG, travoprost monotherapy appeared unable to produce the desirable 30% reduction in average IOP.

• Authors: G S Ang, J P Kersey, L Shepstone, D C Broadway
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 92 Issue 8 Pg. 1129-33 (Aug 2008) ISSN: 1468-2079 [Electronic] England
• PMID: 18511540 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antihypertensive Agents
• Cloprostenol
• Travoprost

Topics

• Aged
• Antihypertensive Agents (therapeutic use)
• Circadian Rhythm
• Cloprostenol (analogs & derivatives, therapeutic use)
• Female
• Follow-Up Studies
• Glaucoma (drug therapy, physiopathology)
• Humans
• Intraocular Pressure (drug effects)
• Male
• Middle Aged
• Single-Blind Method
• Travoprost
• Treatment Outcome