The prognostic impact of M-CSF, CSF-1 receptor, CD68 and CD3 in prostatic carcinoma.

Abstract

AIMS:

Macrophage colony-stimulating factor (M-CSF) binds to colony-stimulating factor-1 receptor (CSF-1R) and stimulates proliferation and differentiation of monocytes, macrophages and their bone marrow progenitors. M-CSF, CSF-1R, the macrophage marker CD68, and the pan T-lymphocyte marker CD3 are increased in many human cancers. Their prognostic importance in primary prostatic carcinoma has not been fully delineated. The aim was to compare the expression of M-CSF, CSF-1R, CD68 and CD3 in metastatic and non-metastatic prostatic cancer.

METHODS AND RESULTS:

Digital video analysis of tumour cell areas and tumour stromal areas was performed in 59 cancer specimens: 32 patients with metastases and 27 patients without metastases. Expression of M-CSF and CSF-1R was recorded as 0 (negative immunoreactivity), 1 (weak), 2 (moderate) or 3 (strong reactivity). Macrophages (CD68) and T lymphocytes (CD3) were detected as proportions of moderately or strongly immunoreactive cells. Patients with metastatic primary cancers showed higher expression of M-CSF (P < 0.0001, P = 0.005), CSF-1R (both P < 0.0001) and CD3 (P = 0.007, P < 0.0001) in both tumour cell areas and tumour stromal areas, compared with the non-metastatic cancers.

CONCLUSION:

This study suggests that expression of M-CSF, CSF-1R and CD3 is a significant prognostic factor in primary prostatic cancers by predicting the development of metastases.

• Authors: E Richardsen, R D Uglehus, J Due, C Busch, L-T R Busund
• Journal: Histopathology (Histopathology) Vol. 53 Issue 1 Pg. 30-8 (Jul 2008) ISSN: 1365-2559 [Electronic] England
• PMID: 18510570 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, CD
• Antigens, Differentiation, Myelomonocytic
• Biomarkers, Tumor
• CD3 Complex
• CD68 antigen, human
• Macrophage Colony-Stimulating Factor
• Receptor, Macrophage Colony-Stimulating Factor
• Prostate-Specific Antigen

Topics

• Adenocarcinoma (diagnosis, metabolism, secondary)
• Adult
• Aged
• Aged, 80 and over
• Antigens, CD (metabolism)
• Antigens, Differentiation, Myelomonocytic (metabolism)
• Biomarkers, Tumor (metabolism)
• CD3 Complex (metabolism)
• Humans
• Macrophage Colony-Stimulating Factor (metabolism)
• Male
• Microscopy, Video
• Middle Aged
• Predictive Value of Tests
• Prognosis
• Prostate-Specific Antigen (blood)
• Prostatectomy
• Prostatic Neoplasms (diagnosis, metabolism, surgery)
• Receptor, Macrophage Colony-Stimulating Factor (metabolism)