Abstract | UNLABELLED: Children with idiopathic nephrotic syndrome (NS) are at risk for a disorder of bone metabolism. The role of metabolites of vitamin D supplements in prevention of this disorder has not been yet clarified. The aim of the study was to evaluate changes in selected bone biochemical markers in children with NS treated with different doses of prednisone and metabolites of vitamin D. METHODS: RESULTS: Mean Cau and Pu values found at T1 were significantly higher and mean values of Ps, AP, PICP, ICTP concentration and PICP/ICTP ratio were significantly lower in 3 groups of pts in comparison to TO. A significant increase of Cas concentration was found in group I and control group, but there were no significant differences among values of Cas in 3 groups. In T2 period PICP and PICP/ICTP ratio increased (T2 vs T1) in all groups, however mean values of AP did not change significantly. Moreover, there was an increase of Cas and decrease of PTH in group I. In group I and II, levels of phosphaturia showed a significant difference among 3 studied groups. CONCLUSIONS:
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Authors | Julita Wojnar, Maria Roszkowska-Blaim, Małgorzata Pańczyk-Tomaszewska |
Journal | Przeglad lekarski
(Przegl Lek)
Vol. 64
Issue 9
Pg. 552-8
( 2007)
ISSN: 0033-2240 [Print] Poland |
Vernacular Title | Ocena dynamiki zmian wybranych parametrów metabolizmu kostnego w czasie stosowania kortykosteroidów i metabolitów witaminy D3 u dzieci z zespołem nerczycowym. |
PMID | 18510075
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Biomarkers
- Glucocorticoids
- Vitamin D
- Prednisone
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Topics |
- Adolescent
- Biomarkers
(blood)
- Bone and Bones
(drug effects, metabolism)
- Child
- Child, Preschool
- Female
- Glucocorticoids
(pharmacology, therapeutic use)
- Humans
- Male
- Nephrotic Syndrome
(drug therapy)
- Prednisone
(pharmacology, therapeutic use)
- Vitamin D
(pharmacology, therapeutic use)
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