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A dose-ranging study of the pharmacokinetics and pharmacodynamics of the selective apoptotic antineoplastic drug (SAAND), OSI-461, in patients with advanced cancer, in the fasted and fed state.

AbstractPURPOSE:
To evaluate the safety, pharmacokinetics and determine the recommended dose of the selective apoptotic antineoplastic drug, OSI-461 administered on a twice-daily regimen to patients with advanced solid malignancies.
METHODS:
In this phase I trial, 33 patients were treated with OSI-461 doses ranging from 400 to 1,200 mg given twice daily in 4-week cycles. Pharmacokinetic studies were performed to characterize the plasma disposition of OSI-461 and the effect of food intake on OSI-461 absorption. Secondary biomarker studies were performed to assess the biologic activity of OSI-461 including the measurement of pGSK-3beta, a PKG substrate, and pharmacogenetic studies to identify polymorphisms of CYP3A that influence drug metabolism and of ABCG2, involved in drug resistance.
RESULTS:
Thirty-three patients were treated with 86 courses of OSI-461. The dose-limiting toxicities were grade 3 abdominal pain, found in one patient at the 1,000 mg BID fed dose level and all patients at the 1,200 mg BID fed dose level. There was also one episode each of grade 3 fatigue and grade 3 constipation at the 1,000 and 1,200 mg BID fed dose levels, respectively. Other common toxicities included mild to moderate fatigue, nausea, anorexia and mild elevation in bilirubin. Pharmacokinetic studies of OSI-461 revealed approximately a twofold increase in AUC(0-24) when OSI-461 was administered with food. An increase in pGSK-3beta post-dose was seen in the majority of patients and was greater at higher dose levels. No patients exhibited CYP3A4 polymorphisms, while 100% of patients were found to have the CYP3A5*3/CYP3A5*3 polymorphism. Two known polymorphisms of the ABCG2 gene, G34 --> A34 and C421 --> A421, occurred at frequencies of 11.76 and 29%, respectively.
CONCLUSIONS:
Toxicity and pharmacodynamic data show that the recommended oral dose of OSI-461 is 800 mg twice daily administered with food. The drug appears to be well-tolerated, and overall bioavailability appears to be markedly increased when the drug is administered with food. These results support further disease-directed evaluations of OSI-461 at a dose of 800 mg BID in combination with other chemotherapeutic agents.
AuthorsC L O'Bryant, C H Lieu, S Leong, R Boinpally, M Basche, L Gore, K Leonardi, M K Schultz, S Hariharan, L Chow, S Diab, A Gibbs, S G Eckhardt
JournalCancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 63 Issue 3 Pg. 477-89 (Feb 2009) ISSN: 1432-0843 [Electronic] Germany
PMID18509645 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • (5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride
  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Sulindac
  • Glycogen Synthase Kinase 3 beta
  • Glycogen Synthase Kinase 3
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents (administration & dosage, adverse effects, pharmacokinetics, pharmacology)
  • Apoptosis (drug effects)
  • Area Under Curve
  • Biomarkers, Tumor (blood)
  • Chromatography, High Pressure Liquid
  • Cohort Studies
  • Fasting
  • Female
  • Food
  • Glycogen Synthase Kinase 3 (blood)
  • Glycogen Synthase Kinase 3 beta
  • Humans
  • Male
  • Middle Aged
  • Neoplasms (drug therapy, genetics, physiopathology)
  • Pharmacogenetics
  • Reference Standards
  • Sulindac (administration & dosage, adverse effects, analogs & derivatives, pharmacokinetics, pharmacology)
  • Tandem Mass Spectrometry

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