Tumor markers in mature cystic teratomas of the ovary.

Abstract

OBJECTIVE:

The objective of this study was to evaluate the serum levels of tumor markers in patients with ovarian mature cystic teratomas.

METHOD:

Retrospective study of 215 patients operated at Zekai Tahir Burak Women Health Education and Research Hospital between January 2001 and October 2006 was performed.

RESULTS:

The median age was 36 years (range 13-80). The mean tumor diameter was 7.7 +/- 4.6 cm (range 2-25). The mean serum CA 125 level was 26.2 +/- 29.9 U/mL (range 1.4-225, normal value <35), and the mean serum CA 19-9 level was 83.5 +/- 179.2 IU/mL (range 0.6-1,000; normal value <37). The elevated rate of CA 19-9, CA 125 was 39.6% (74/187) and 23.3% (50/215), respectively. The mean age of patients and the rate of bilaterality of tumors were similar in both patients with elevated CA19-9 and with normal CA 19-9 level (P > 0.05). The mean tumor size of patients with elevated CA 19-9 was greater than those with normal CA19-9 level (P = 0.01).

CONCLUSION:

Serum CA 19-9 has the highest positivity rate among other tumor markers in ovarian mature cystic teratomas. Elevated serum CA 19-9 levels are correlated with larger tumor size. But the diagnostic value of elevated CA 19-9 in patients with MCT would be poor if the test was used alone.

• Authors: Emin Ustunyurt, Ustunyurt Emin, Tayfun Gungor, Gungor Tayfun, Cantekin Iskender, Iskender Cantekin, Basak Ozlem Ustunyurt, Ustunyurt Basak Ozlem, Umit Bilge, Bilge Umit, Leyla Mollamahmutoglu, Mollamahmutoglu Leyla
• Journal: Archives of gynecology and obstetrics (Arch Gynecol Obstet) Vol. 279 Issue 2 Pg. 145-7 (Feb 2009) ISSN: 1432-0711 [Electronic] Germany
• PMID: 18506458 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• CA-125 Antigen
• CA-19-9 Antigen
• Carcinoembryonic Antigen
• Mucin-1
• alpha-Fetoproteins

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (blood)
• CA-125 Antigen (blood)
• CA-19-9 Antigen (blood)
• Carcinoembryonic Antigen (blood)
• Female
• Humans
• Hysterectomy
• Middle Aged
• Mucin-1 (blood)
• Ovarian Neoplasms (blood, pathology, surgery)
• Ovariectomy
• Retrospective Studies
• Teratoma (blood, pathology, surgery)
• alpha-Fetoproteins (analysis)