| Abstract | Resistin has been linked to components of the metabolic syndrome, including obesity, insulin resistance, and hyperlipidemia. We hypothesized that resistin deficiency would reverse hyperlipidemia in genetic obesity. C57Bl/6J mice lacking resistin [resistin knockout (RKO)] had similar body weight and fat as wild-type mice when fed standard rodent chow or a high-fat diet. Nonetheless, hepatic steatosis, serum cholesterol, and very low-density lipoprotein (VLDL) secretion were decreased in diet-induced obese RKO mice. Resistin deficiency exacerbated obesity in ob/ob mice, but hepatic steatosis was drastically attenuated. Moreover, the levels of triglycerides, cholesterol, insulin, and glucose were reduced in ob/ob-RKO mice. The antisteatotic effect of resistin deficiency was related to reductions in the expression of genes involved in hepatic lipogenesis and VLDL export. Together, these results demonstrate a crucial role of resistin in promoting hepatic steatosis and hyperlipidemia in obese mice. |
| Authors | Neel S Singhal, Rajesh T Patel, Yong Qi, Yun-Sik Lee, Rexford S Ahima
(Affiliation: Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Blvd., Philadelphia, PA 19104, USA.)
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| Journal | American journal of physiology. Endocrinology and metabolism
(Am J Physiol Endocrinol Metab)
Vol. 295
Issue 2
Pg. E331-8
(Aug 2008)
ISSN: 0193-1849 United States |
| PMID | 18505833
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
| Chemical References |
- Adiponectin
- Blood Glucose
- Leptin
- Lipoproteins, VLDL
- Resistin
- Triglycerides
- Insulin
- Cholesterol
|
| Topics |
- Adiponectin
(blood)
- Animals
- Blood Glucose
(metabolism)
- Body Weight
(physiology)
- Cholesterol
(blood, secretion)
- Cohort Studies
- Fatty Liver
(genetics, metabolism)
- Hyperlipidemias
(genetics, metabolism)
- Immunohistochemistry
- Insulin
(blood)
- Leptin
(deficiency, metabolism)
- Lipoproteins, VLDL
(blood)
- Liver
(metabolism, secretion)
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Obese
- Obesity
(genetics, metabolism)
- Resistin
(deficiency, genetics, metabolism)
- Triglycerides
(blood, secretion)
|
