Abstract | BACKGROUND:
Malnutrition is very prevalent among patients with chronic renal failure. The role of derangements in the gut-brain axis for regulation of appetite in the genesis of anorexia of these patients has not been adequately investigated. Design. Following a randomized, crossover design, we analysed plasma levels of peptide YY (PYY)(1-36) and PYY(3-36) both fasting and after a standardized oral mixed meal or intraperitoneal glucose infusion in 10 stable uraemic patients undergoing peritoneal dialysis and 8 healthy controls, matched for age, gender and body mass index. Main results. Median baseline plasma levels of PYY(1-36) in the different provocation tests oscillated between 406 and 460 pg/mL in patients, as compared with 73 and 100 pg/mL in controls (P < 0.001). Corresponding values for PYY(3-36) oscillated between 235 and 267 pg/mL in patients, versus 56 and 70 pg/mL in controls (P < 0.001). The association of high levels of PYY(3-36) and normal levels of acylated ghrelin (when compared with healthy controls) configurated a markedly pro-anorexigenic pattern in patients. Neither oral intake nor intraperitoneal glucose resulted in significant changes in plasma levels of PYY(1-36) or PYY(3-36) in subjects with renal failure, in contrast with the expected postprandial rise observed in healthy controls (41% for PYY(1-36), P = 0.04 and 32% for PYY(3-36), P = 0.02, median values). CONCLUSIONS:
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Authors | Miguel Pérez-Fontán, Fernando Cordido, Ana Rodríguez-Carmona, Manuel Penín, Helena Díaz-Cambre, Andrés López-Muñiz, Susana Sangiao-Alvarellos, Jesús García-Buela |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 23
Issue 11
Pg. 3696-703
(Nov 2008)
ISSN: 1460-2385 [Electronic] England |
PMID | 18503008
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dialysis Solutions
- Peptide YY
- Glucose
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Topics |
- Adult
- Aged
- Anorexia
(etiology, physiopathology)
- Appetite
(physiology)
- Case-Control Studies
- Chronic Disease
- Cross-Over Studies
- Dialysis Solutions
(pharmacology)
- Female
- Food, Formulated
- Glucose
(administration & dosage, pharmacology)
- Humans
- Infusions, Parenteral
- Male
- Malnutrition
(etiology, physiopathology)
- Middle Aged
- Peptide YY
(blood)
- Peritoneal Dialysis
- Renal Insufficiency
(blood, complications, therapy)
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