Circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease 2 in endemic pemphigus foliaceus.

Abstract

Endemic pemphigus foliaceus (EPF) is an autoimmune disease, which occurs in Brazil and other regions of South America. Mannose-binding lectin (MBL) and MBL-associated serine protease (MASP-2) play a key role in innate immunity, and its deficiency has been related to increased susceptibility to infection and autoimmune diseases. MBL and MASP-2 serum levels were measured in 114 patients with EPF and in 100 healthy individuals in Brazil. MBL and MASP-2 levels were measured by sandwich assays (time-resolved immunofluorimetic assay) using monoclonal antibodies. No difference was observed in the MBL level in patients with EPF compared with controls [mean +/- SEM 1230.07 +/- 132.18 ng/mL (median 789.0 ng/mL) vs. 1036.98 +/- 117.99 ng/mL (median 559.5 ng/mL), P = 0.32]. Non-significant lower MASP-2 levels were observed in EPF [274.34 +/- 15.66 ng/mL (median 239.5 ng/mL ) vs. 304.72 +/- 15.28 ng/mL [median 261.0 ng/mL ), P = 0.06]. MBL deficiency (< 10 ng/mL) or MASP-2 deficiency (< 100 ng/mL) did not differ significantly between patients and controls. These data indicate that MBL and MASP-2 deficiency are not associated with susceptibility to EPF.

• Authors: I Messias-Reason, D G Bosco, R M Nisihara, L H Jakobsen, M L Petzl-Erler, J C Jensenius
• Journal: Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 33 Issue 4 Pg. 495-7 (Jul 2008) ISSN: 1365-2230 [Electronic] England
• PMID: 18498410 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Mannose-Binding Lectin
• MASP2 protein, human
• Mannose-Binding Protein-Associated Serine Proteases

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Child
• Complement Pathway, Classical (immunology)
• Female
• Genotype
• Humans
• Male
• Mannose-Binding Lectin (metabolism)
• Mannose-Binding Protein-Associated Serine Proteases (metabolism)
• Middle Aged
• Pemphigus (immunology, metabolism)